ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Release of ATP in the lung evoked by inhalation of irritant gases in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- TRP channels in airway sensory nerves.Neuroscience letters · 2021Review
- The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs.Respiratory research · 2021Article
- Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.Frontiers in physiology · 2021Review
- Airway Innervation and Plasticity in Asthma.Physiology (Bethesda, Md.) · 2019Review
- Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Hypersensitivity of vagal pulmonary C-fibers induced by increasing airway temperature in ovalbumin-sensitized rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse.Respiratory physiology & neurobiology · 2015Article
- Peripheral neural circuitry in cough.Current opinion in pharmacology · 2015Review
- Mechanisms underlying the neuronal-based symptoms of allergy.The Journal of allergy and clinical immunology · 2014Review
- Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors.PloS one · 2014Article
- Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge.The Journal of physiology · 2012Article
- Vagal afferent nerves with the properties of nociceptors.Autonomic neuroscience : basic & clinical · 2010Article
- Respiratory sensations evoked by activation of bronchopulmonary C-fibers.Respiratory physiology & neurobiology · 2009Review
- Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effect of ovalbumin (Ova) sensitization on pulmonary C-fiber sensitivity was investigated. Brown-Norway rats were sensitized by intraperitoneal injection of Ova followed by aerosolized Ova three times per week for 3 wk. Control rats received the vehicle. At the end of the third week, single-unit fiber activities (FA) of pulmonary C fibers were recorded in anesthetized, artificially ventilated rats. Our results showed the following: 1) Ova sensitization induced airway inflammation (infiltration of eosinophils and neutrophils) and airway hyperresponsiveness in rats; 2) baseline FA in sensitized rats was significantly higher than that in control ones; 3) similarly, the pulmonary C-fiber response to right atrial injection of capsaicin was markedly higher in sensitized rats, which were significantly amplified after the acute Ova inhalation challenge; and 4) similar patterns, but smaller magnitudes of the differences in C-fiber responses to adenosine and lung inflation, were also found between sensitized and control rats. In conclusion, Ova sensitization elevated the baseline FA and excitability of pulmonary C fibers, and the hypersensitivity was further potentiated after the acute Ova inhalation challenge in sensitized rats. Chronic allergic inflammatory reactions in the airway probably contributed to the sensitizing effect on these lung afferents.
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