ReviewJournal of medical microbiology2008
Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis.
Review in Journal of medical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity.Infection · 2024Pooled it
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- The immunopathogenesis ofFrontiers in microbiology · 2024Review
- Protective Effects of Silibinin onJournal of cancer prevention · 2021Article
- Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori.Journal of gastrointestinal cancer · 2021Observational
- New genotypes of Helicobacter Pylori VacA d-region identified from global strains.BMC molecular and cell biology · 2021Article
- Four Chromosomal Type IV Secretion Systems inFrontiers in microbiology · 2020Review
- Pathogenesis and clinical management ofWorld journal of gastroenterology · 2019Review
- The role of integrating conjugative elements in Helicobacter pylori: a review.Journal of biomedical science · 2018Review
- Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis.World journal of clinical oncology · 2018Review
- Distribution and clinical associations of integrating conjugative elements and cag pathogenicity islands of Helicobacter pylori in Indonesia.Scientific reports · 2018Article
- Article
- Application of FLP-FRT System to Construct Unmarked Deletion inFrontiers in microbiology · 2017Article
- Protein signature characterizingInfectious agents and cancer · 2017Article
- Construction of Novel Plasmid Vectors for Gene Knockout in Helicobacter pylori.Current microbiology · 2016Article
- Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India.Gut pathogens · 2016Article
- Helicobacter pylori with the Intact dupA Cluster is more Virulent than the Strains with the Incomplete dupA Cluster.Current microbiology · 2015Article
- Article
- The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases.Gastroenterology and hepatology from bed to bench · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Putative virulence genes of Helicobacter pylori are generally classified into three categories: strain-specific genes, phase-variable genes and genes with variable structures/genotypes. Among these, there has recently been considerable interest in strain-specific genes found outside of the cag pathogenicity island, especially genes in the plasticity regions. Nearly half of the strain-specific genes of H. pylori are located in the plasticity regions in strains 26695 and J99. Strain HPAG1, however, seems to lack a typical plasticity region; instead it has 43 HPAG1-specific genes which are either undetectable or incompletely represented in the genomes of strains 26695 and J99. Recent studies showed that certain genes or combination of genes in this region may play important roles in the pathogenesis of H. pylori-associated gastroduodenal diseases. Most previous studies have focused on the plasticity region in strain J99 (jhp0914-jhp0961) and the jhp0947 gene and the duodenal ulcer promoting (dupA) gene are good candidate markers for gastroduodenal diseases although there are some paradoxical findings. The jhp0947 gene is reported to be associated with an increased risk of both duodenal ulcers and gastric cancers, whereas the dupA gene, which encompasses jhp0917 and jhp0918, is reported to be associated with an increased risk of duodenal ulcers and protection against gastric cancers. In addition, recent studies showed that approximately 10-30 % of clinical isolates possess a 16.3 kb type IV secretion apparatus (tfs3) in the plasticity region. Studies on the plasticity region have only just begun, and further investigation is necessary to elucidate the roles of genes in this region in gastroduodenal pathogenesis.
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