ArticleAmerican journal of epidemiology2008
Maternal asthma medication use and the risk of gastroschisis.
Article in American journal of epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Medication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies.Orphanet journal of rare diseases · 2024Pooled it
- Interventions for managing asthma in pregnancy.The Cochrane database of systematic reviews · 2014Pooled it
- Preconception care: screening and management of chronic disease and promoting psychological health.Reproductive health · 2014Pooled it
- Complex interplays: Asthma management and maternal‑fetal outcomes in pregnancy (Review).Experimental and therapeutic medicine · 2024Review
- Time trends, geographic variation and risk factors for gastroschisis in Canada: A population-based cohort study 2006-2017.Paediatric and perinatal epidemiology · 2021Article
- The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities.The Journal of allergy and clinical immunology · 2021Article
- Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology.Clinical and molecular allergy : CMA · 2020Review
- A machine learning approach to investigate potential risk factors for gastroschisis in California.Birth defects research · 2019Article
- Gastroschisis and Cumulative Stressor Exposures.Epidemiology (Cambridge, Mass.) · 2018Article
- Maternal ambient heat exposure during early pregnancy in summer and spring and congenital heart defects - A large US population-based, case-control study.Environment international · 2018Article
- Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study.BJOG : an international journal of obstetrics and gynaecology · 2016Article
- Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS).Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- Allergen immunotherapy in pregnancy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2015Review
- Diagnosing rhinitis during pregnancy.Current allergy and asthma reports · 2014Review
- Safety of bronchodilators and corticosteroids for asthma during pregnancy: what we know and what we need to do better.Journal of asthma and allergy · 2013Review
- The National Center on Birth Defects and Developmental Disabilities: past, present, and future.American journal of preventive medicine · 2012Article
- Article
- Asthma in pregnancy - from immunology to clinical management.Multidisciplinary respiratory medicine · 2010Article
- Effect of pregnancy on maternal asthma symptoms and medication use.Obstetrics and gynecology · 2010Article
- Is there epidemiologic evidence to support vascular disruption as a pathogenesis of gastroschisis?American journal of medical genetics. Part A · 2009Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
The objective of this study was to examine the association between maternal asthma medication use during the periconceptional period and the risk of gastroschisis. In this case-control study, the authors used data on deliveries enrolled in the National Birth Defects Prevention Study (1997-2002) from eight collaborating centers. The cases included 381 infants with isolated gastroschisis, and the controls were 4,121 liveborn infants without malformations. The asthma medications used during the periconceptional period (1 month prepregnancy through the third pregnancy month) were divided into two groups, antiinflammatory and bronchodilator, and analyzed separately. Users of multiple asthma medications during the periconceptional period were also examined. Logistic regression was used to estimate odds ratios and 95% confidence intervals while controlling for maternal age, race/ethnicity, education, smoking, folic acid/vitamin use, and other vasoactive medications. Maternal bronchodilator use showed an elevated statistically significant risk of gastroschisis (adjusted odds ratio = 2.06, 95% confidence interval: 1.19, 3.59). No significant association was found between maternal use of asthma antiinflammatory medications and gastroschisis. Because information on maternal asthma status/severity was not available, the effects of disease on the risk of gastroschisis cannot be ruled out. Additional research is needed in determining whether a real risk exists and for guiding asthma treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.