ArticleFEBS letters2008
A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse.
Article in FEBS letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Network Pharmacology-Based Study of Citrus medica L. Ethanol Extract Combating Obesity in Caenorhabditis elegans via Dual Action on AAK-2/NHR-49 and MDT-15/SBP-1 Pathways.Chemistry & biodiversity · 2026Article
- Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury.Cell chemical biology · 2024Article
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- A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automatedHeliyon · 2022Article
- Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation ineLife · 2022Article
- Quo VadisMetabolites · 2021Review
- An alternative food source for metabolism and longevity studies in Caenorhabditis elegans.Communications biology · 2021Article
- Seasonally Related Disruption of Metabolism by Environmental Contaminants in Male Goldfish (Frontiers in toxicology · 2021Article
- Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.Nature metabolism · 2020Article
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- IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Metabolic Insights Into the Effects of Nutrient Stress onFrontiers in molecular biosciences · 2019Article
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- Lipidomic Analysis ofBio-protocol · 2017Article
- Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans.Journal of medicinal food · 2016Article
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- Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.Nutrition research (New York, N.Y.) · 2015Article
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Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Proton Nuclear Magnetic Resonance spectroscopy and Gas Chromatography Mass Spectrometry based metabolomics has been used in conjunction with multivariate statistics to examine the metabolic changes in Caenorhabditis elegans following the deletion of nuclear hormone receptor-49 (nhr-49). Deletion of the receptor produced profound changes in fatty acid metabolism, in particular an increase in the ratio of unsaturated to saturated fatty acids, a decrease in the concentration of glucose and increases in lactate and alanine. Given the proposed functional similarity between nhr-49 and the mammalian peroxisome proliferator-activated receptors (PPARs) these changes were compared with the metabolome of the PPAR-alpha null mouse. The metabolomic approach demonstrated a number of similarities including the regulation of lipid synthesis, beta-oxidation of fatty acids and changes in glycolysis/gluconeogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.