ReviewClinical and experimental immunology2008
Establishing humanized mice using stem cells: maximizing the potential.
Review in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Model Systems of Gammaherpesvirus Infection, Immunity, and Disease.Journal of medical virology · 2025Review
- Humanized Mice as a Model to Assess the Response of Human Hematopoietic Stem Cells to Irradiation.Bulletin of experimental biology and medicine · 2023Article
- Patient-derived precision cut tissue slices from primary liver cancer as a potential platform for preclinical drug testing.EBioMedicine · 2023Article
- Humanized Mouse Model of HIV Infection.Bulletin of experimental biology and medicine · 2023Article
- Advances in Research of Adult Gliomas.International journal of molecular sciences · 2021Review
- An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses.Cancer immunology research · 2019Article
- Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response.Journal of visualized experiments : JoVE · 2017Article
- Application of Humanized Mice in Immunological Research.Methods in molecular biology (Clifton, N.J.) · 2016Review
- Host specificity of bacterial pathogens.Cold Spring Harbor perspectives in medicine · 2013Review
- New cast for a new era: preclinical cancer drug development revisited.The Journal of clinical investigation · 2013Review
- Study human pancreatic cancer in mice: how close are they?Biochimica et biophysica acta · 2013Review
- Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?Regenerative medicine · 2011Article
- Dengue virus markers of virulence and pathogenicity.Future virology · 2009Article
- Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.Clinical and experimental immunology · 2008Article
- Mouse xenograft models vs GEM models for human cancer therapeutics.Disease models & mechanismsArticle
- Humanized mouse models of HIV infection.AIDS reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Studies on physiology and pathology as they relate to the immune system draw heavily upon rodent models. With the increasing impetus provided by initiatives in translational medicine, the demand for ever more sophisticated, 'humanized' murine models is greater than ever. However, the design and implementation of studies in such mice is far from trivial. Here we provide a technical perspective on the increasing interest in developing humanized mice. We give examples of primary data starting with the routine procurement of human donor material, through CD34(+) cell purification prior to engraftment to injection into immunocompromised mice. Our goal is to provide practical advice to the many investigators who may be commencing or considering such studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.