ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Independent evolution toward larger body size in the distinctive Faroe Island mice.G3 (Bethesda, Md.) · 2021Pooled it
- Article
- Genetic Dissection of a QTL Affecting Bone Geometry.G3 (Bethesda, Md.) · 2017Article
- Enhanced cartilage repair in 'healer' mice-New leads in the search for better clinical options for cartilage repair.Seminars in cell & developmental biology · 2017Review
- Article
- Multivariate Analysis of Genotype-Phenotype Association.Genetics · 2016Article
- Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.BMC genomics · 2015Article
- Impacts of genetic correlation on the independent evolution of body mass and skeletal size in mammals.BMC evolutionary biology · 2014Article
- Article
- Genomic correlates of relationship QTL involved in fore- versus hind limb divergence in mice.Genome biology and evolution · 2013Article
- Milk ejection in mice LG/J x SM/J.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Heritability of articular cartilage regeneration and its association with ear wound healing in mice.Arthritis and rheumatism · 2012Article
- Hypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strains.Brain and behavior · 2012Article
- Article
- Haplotype probabilities in advanced intercross populations.G3 (Bethesda, Md.) · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Genetic architecture of nest building in mice LG/J × SM/J.Frontiers in genetics · 2012Article
- Article
- Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionStudy of mutations with large phenotypic effects has allowed the identification of key players in skeletal development. However, the molecular nature of variation in large, phenotypically normal populations tends to be characterized by smaller phenotypic effects that remain undefined. MATERIALS AND
methodsWe use interval mapping and quantitative trait locus (QTL) mapping techniques in the combined F2-F3 populations (n = 2111) of an LG/J x SM/J mouse intercross to detect QTLs associated with the lengths of the humerus, ulna, femur, and tibia.
resultsSeventy individual trait QTLs affecting long bone lengths were detected, with several chromosomes harboring multiple QTLs. The genetic architecture suggests mainly small, additive effects on long bone length, with roughly one third of the QTLs displaying dominance. Sex interactions were common, and four sex-specific QTLs were observed. Pleiotropy could not be rejected for most of the QTLs identified. Thirty-one epistatic interactions were detected, almost all affecting regions including or immediately adjacent to QTLs.
conclusionsA complex regulatory network with many gene interactions modulates bone growth, possibly with integrated skeletal modules that allow fine-tuning of developmental processes present. Candidate genes in the QTL CIs include many genes known to affect endochondral bone growth and genes that have not yet been associated with bone growth or body size but have a strong potential to influence these traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.