ArticleJournal of the American Society of Nephrology : JASN2008
A critical role for vascular smooth muscle in acute glucocorticoid-induced hypertension.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Article
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- Impact of Blood Pressure on Allograft Function and Survival in Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- CmPn/CmP Signaling Networks in the Maintenance of the Blood Vessel Barrier.Journal of personalized medicine · 2023Review
- Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review).International journal of molecular medicine · 2022Review
- Hypertension in kidney transplant recipients.World journal of transplantation · 2022Review
- Adverse Effects of Immunosuppression: Nephrotoxicity, Hypertension, and Metabolic Disease.Handbook of experimental pharmacology · 2022Article
- Neutrophil gelatinase-associated lipocalin as an immunomodulator in endocrine hypertension.Frontiers in endocrinology · 2022Review
- Update on Treatment of Hypertension After Renal Transplantation.Current hypertension reports · 2021Review
- Predisposition of Women to Cardiovascular Diseases: A Side-Effect of Increased Glucocorticoid Signaling During the COVID-19 Pandemic?Frontiers in global women's health · 2021Review
- Seminal Plasma Triggers the Differential Expression of the Glucocorticoid Receptor (Animals : an open access journal from MDPI · 2020Article
- NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess.Redox biology · 2020Article
- Glucocorticoid Signaling and the Aging Heart.Frontiers in endocrinology · 2020Review
- Review
- Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.The Journal of endocrinology · 2019Article
- Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves.Frontiers in neuroscience · 2019Article
- Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice.Endocrinology · 2018Review
- Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.International journal of molecular sciences · 2017Review
- Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury.Scientific reports · 2017Article
- Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis.The Journal of endocrinology · 2017Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Although glucocorticoid (GC)-induced hypertension has commonly been attributed to promiscuous activation of the mineralocorticoid receptor by cortisol, thereby promoting excess reabsorption of sodium and water, numerous lines of evidence indicate that this is not the only or perhaps even the primary mechanism. GC induce a number of effects on vascular smooth muscle (VSM) in vitro that may be pertinent to hypertension, but their contribution in vivo is unknown. To address this question, a mouse model with a tissue-specific knockout (KO) of the GC receptor in the VSM was created and characterized. Similar to control mice, KO mice exhibited normal baseline BP and, interestingly, showed normal circadian variation in BP. When dexamethasone was administered, however, the acute hypertensive response was markedly attenuated in KO mice, and there was a trend toward a decreased chronic hypertensive response. These data suggest that the GC receptor in VSM plays a critical role in the acute hypertensive response to GC in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.