Evidence map›Paper›PMID 18434555›Full record

ArticleJournal of clinical microbiology2008

Unusually high prevalence of panton-valentine leukocidin genes among methicillin-sensitive Staphylococcus aureus strains carried in the Indonesian population.

Juliëtte A Severin, Endang Sri Lestari, Kuntaman Kuntaman, Damian C Melles, Martijn Pastink, Justine K Peeters, Susan V Snijders, Usman Hadi, D Offra Duerink, Alex van Belkum and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 48 citations in OpenAlex.

  1. Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022
    Review
  2. Article
  3. Nasal Methicillin-ResistantOpen forum infectious diseases · 2021
    Article
  4. Reducing transmission of methicillin-resistantInfection prevention in practice · 2019
    Article
  5. Review
  6. Article
  7. Staphylococcus aureus nasal carriage among healthcare workers in Kisangani, the Democratic Republic of the Congo.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015
    Article
  8. Article
  9. Article
  10. Article
  11. Community-associated methicillin-resistant Staphylococcus aureus case studies.Methods in molecular biology (Clifton, N.J.) · 2014
    Review
  12. Bovine-associated MRSA ST398 in the Netherlands.Acta veterinaria Scandinavica · 2012
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Juliëtte A SeverinDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, Rotterdam, The Netherlands. j.severin@erasmusmc.nl
Endang Sri Lestari
Kuntaman Kuntaman
Damian C Melles
Martijn Pastink
Justine K Peeters
Susan V Snijders
Usman Hadi
D Offra Duerink
Alex van Belkum
Henri A Verbrugh
Antimicrobial Resistance in Indonesia, Prevalence and Prevention Study Group
Erasmus MC · NLAirlangga University · IDDiponegoro University · IDLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few data on the molecular characteristics and epidemiology of Staphylococcus aureus from Indonesia are available. The purpose of the present study was to define S. aureus reservoirs in both the Indonesian community and hospital using a collection of 329 nasal carriage isolates obtained during a survey of 3,995 healthy individuals and patients from Java, Indonesia. Only one strain (0.3%) was identified as methicillin-resistant S. aureus by mecA gene PCR. The Panton-Valentine leukocidin (PVL) genes were detected in 35 methicillin-sensitive S. aureus strains (10.6%). Molecular typing by pulsed-field gel electrophoresis of the 329 isolates showed extensive genetic diversity among both PVL-positive and PVL-negative strains. In Surabaya, Indonesia, however, a cluster was identified that was strongly associated with the presence of the PVL locus (P < 0.0001). As determined by high-throughput amplified fragment length polymorphism, PVL-positive strains occurred throughout all major AFLP clusters (I to IV). Multilocus sequence typing of a subset of isolates showed that most PVL-positive strains belonged to sequence type (ST) 188, while most PVL-negative isolates belonged to ST45. The high prevalence of PVL-positive S. aureus strains in certain regions of Indonesia is of concern since these strains may cause severe infections in the community and in hospitals.

Indexed as

Anti-Bacterial AgentsBacterial ToxinsCarrier StateElectrophoresis, Gel, Pulsed-FieldExotoxinsHumansIndonesiaLeukocidinsMethicillinMolecular EpidemiologyNasal CavityPolymorphism, Restriction Fragment LengthPrevalenceStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBacterial ToxinsExotoxinsLeukocidinsMethicillinPanton-Valentine leukocidin

Identifiers

PMID18434555
PMCPMC2446829
OpenAlexW2120297245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.