ArticleDevelopment (Cambridge, England)2008
Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells.Life science alliance · 2025Article
- Loss of HD-PTP function results in lipodystrophy, defective cellular signaling and altered lipid homeostasis.Journal of cell science · 2024Article
- Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities.G3 (Bethesda, Md.) · 2023Article
- Long Non-Coding RNAInsects · 2022Article
- Roles of Membrane and Vesicular Traffic in Regulation of the Hippo Pathway.Frontiers in cell and developmental biology · 2019Review
- TheJournal of cell science · 2018Article
- Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.The Journal of biological chemistry · 2018Article
- Myopic (HD-PTP, PTPN23) selectively regulates synaptic neuropeptide release.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mutations of PTPN23 in developmental and epileptic encephalopathy.Human genetics · 2017Article
- A mutant O-GlcNAcase enriches Drosophila developmental regulators.Nature chemical biology · 2017Article
- EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation.PLoS genetics · 2017Article
- Co-culture Activation of MAP Kinase in Drosophila S2 Cells.Methods in molecular biology (Clifton, N.J.) · 2017Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.The Biochemical journal · 2015Article
- The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled.Molecular biology of the cell · 2015Article
- Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells.Genetics · 2015Article
- Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation.Development (Cambridge, England) · 2015Article
- An ESCRT module is required for neuron pruning.Scientific reports · 2015Article
- The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.Developmental cell · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Endocytosis of activated receptors can control signaling levels by exposing the receptors to novel downstream molecules or by instigating their degradation. Epidermal growth factor receptor (EGFR) signaling has crucial roles in development and is misregulated in many cancers. We report here that Myopic, the Drosophila homolog of the Bro1-domain tyrosine phosphatase HD-PTP, promotes EGFR signaling in vivo and in cultured cells. myopic is not required in the presence of activated Ras or in the absence of the ubiquitin ligase Cbl, indicating that it acts on internalized EGFR, and its overexpression enhances the activity of an activated form of EGFR. Myopic is localized to intracellular vesicles adjacent to Rab5-containing early endosomes, and its absence results in the enlargement of endosomal compartments. Loss of Myopic prevents cleavage of the EGFR cytoplasmic domain, a process controlled by the endocytic regulators Cbl and Sprouty. We suggest that Myopic promotes EGFR signaling by mediating its progression through the endocytic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.