ArticleJournal of virology2008
Critical role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Newcastle disease virus induces clathrin-mediated endocytosis to establish infection through the activation of PI3K/AKT signaling pathway by VEGFR2.Journal of virology · 2024Article
- Review
- Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication.Journal of virology · 2018Article
- The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival.PLoS pathogens · 2016Article
- Manipulation of the host cell membrane by human γ-herpesviruses EBV and KSHV for pathogenesis.Virologica Sinica · 2016Review
- The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication.Journal of virology · 2016Article
- Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi's sarcoma and non-Kaposi's cases.Journal of experimental & clinical cancer research : CR · 2015Article
- KSHV: pathways to tumorigenesis and persistent infection.Advances in virus research · 2014Review
- A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB.PloS one · 2010Article
- Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1.Oncogene · 2010Article
- Article
- Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.Cancer letters · 2010Review
- Syk and pTyr'd: Signaling through the B cell antigen receptor.Biochimica et biophysica acta · 2009Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the gammaherpesvirus family. KSHV is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The first open reading frame of the KSHV genome encodes a type 1 transmembrane glycoprotein named K1. K1 is structurally similar to the B-cell receptor (BCR), and its cytoplasmic tail contains an immunoreceptor tyrosine-based activation motif that can activate Syk kinase and the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Recent evidence suggests that receptor signaling occurs not only at the cell membrane, but from intracellular compartments as well. We have found that K1 is internalized in a clathrin-dependent manner, and efficient internalization is coupled to its signaling function. Once internalized, K1 traffics from the early endosome to the recycling endosome. Interestingly, blocking K1's activation of Syk and PI3K prevents K1 from internalizing. We have also found that blocking clathrin-mediated endocytosis prevents downstream signaling by K1. These results strongly suggest that internalization of K1 is intimately associated with normal signaling. When K1 internalization was examined in B lymphocytes, we found that K1 cointernalized with the BCR. Altogether, these results suggest that K1's signaling function is tightly coupled to its internalization.
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