ArticleOsteoarthritis and cartilage2008
Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians.
Article in Osteoarthritis and cartilage, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- Pooled it
- An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity.Journal of orthopaedic surgery and research · 2017Pooled it
- Association between aspartic acid repeat polymorphism of the asporin gene and risk of knee osteoarthritis: A systematic review and meta-analysis.Acta orthopaedica et traumatologica turcica · 2017Pooled it
- A meta-analysis of the relationship between aspartic acid (D)-repeat polymorphisms in asporin and osteoarthritis susceptibility.Rheumatology international · 2014Pooled it
- Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.BMC genetics · 2017Trial
- Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis.Molecular medicine reports · 2019Article
- Multifaceted Roles of Asporin in Cancer: Current Understanding.Frontiers in oncology · 2019Review
- Genetic polymorphism in the asporin gene is not a key risk factor for osteoarthritis: Evidence based on an updated cumulative meta-analysis.Experimental and therapeutic medicine · 2018Article
- Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Etiology of osteoarthritis: genetics and synovial joint development.Nature reviews. Rheumatology · 2012Review
- Age-dependent alteration of TGF-β signalling in osteoarthritis.Cell and tissue research · 2012Review
- Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese.Arthritis research & therapy · 2011Article
- Genetic epidemiology of hip and knee osteoarthritis.Nature reviews. Rheumatology · 2011Review
- Developments in the scientific understanding of osteoarthritis.Arthritis research & therapy · 2009Review
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
Abstract
objectiveAn association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations. The aim of this study was to assess the association of variants in the ASPN gene with the presence of radiographic hand and/or knee OA in a US Caucasian population.
methodsTen single nucleotide polymorphisms (SNPs) within the ASPN gene were genotyped in 775 affected siblings with radiographically confirmed hand and/or knee OA, and the allelic, genotypic and haplotypic association results were examined.
resultsOne variant (SNP RS7033979) showed nominal evidence of association with both hand OA (P=0.042) and knee OA (P=0.032). Four additional SNPs showed nominal evidence of association with knee OA only. These associations were only observed with genotypic tests; the corresponding allelic and haplotype tests did not corroborate the single-point association results.
conclusionThese data suggest that polymorphisms within ASPN are not a major influence in susceptibility to hand or knee OA in US Caucasians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.