ArticleThe Plant journal : for cell and molecular biology2008
CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock.
Article in The Plant journal : for cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Time- and space-resolved transcriptional regulation in Arabidopsis thaliana.Plant biology (Stuttgart, Germany) · 2026Article
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- Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.Plant physiology · 2018Article
- Dancing in the dark: darkness as a signal in plants.Plant, cell & environment · 2017Review
- Characterization of the CCT family and analysis of gene expression in Aegilops tauschii.PloS one · 2017Article
- The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing.The Plant cell · 2016Article
- The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.Plant & cell physiology · 2016Article
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- Genome-Wide Transcriptional Profiling to Elucidate Key Candidates Involved in Bud Burst and Rattling Growth in a Subtropical Bamboo (Frontiers in plant science · 2016Article
- The time of day effects of warm temperature on flowering time involve PIF4 and PIF5.Journal of experimental botany · 2014Article
- Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.The arabidopsis book · 2014Article
- Multiple layers of posttranslational regulation refine circadian clock activity in Arabidopsis.The Plant cell · 2014Review
- Partners in time: EARLY BIRD associates with ZEITLUPE and regulates the speed of the Arabidopsis clock.Plant physiology · 2011Article
- Robust circadian rhythms of gene expression in Brassica rapa tissue culture.Plant physiology · 2010Article
- An expanding universe of circadian networks in higher plants.Trends in plant science · 2010Review
- Ambient temperature response establishes ELF3 as a required component of the core Arabidopsis circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Do trees grow on money? Auxin as the currency of the cellular economy.Cold Spring Harbor perspectives in biology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
summaryThe circadian clock is the endogenous timer that coordinates physiological processes with daily and seasonal environmental changes. In Arabidopsis thaliana, establishment of the circadian period relies on targeted degradation of TIMING OF CAB EXPRESSION 1 (TOC1) by the 26S proteasome. ZEITLUPE (ZTL) is the F-box protein that associates with the SCF (Skp/Cullin/F-box) E3 ubiquitin ligase that is responsible for marking TOC1 for turnover. CULLIN1 (CUL1) is a core component of SCF complexes and is involved in multiple signaling pathways. To assess the contribution of CUL1-containing SCF complexes to signaling within the plant oscillator, circadian rhythms were examined in the recessive, temperature-sensitive CUL1 allele axr6-3. The activity of CUL1 in this mutant declines progressively with increasing ambient temperature, resulting in more severe defects in CUL1-dependent activities at elevated temperature. Examination of circadian rhythms in axr6-3 revealed circadian phenotypes comparable to those observed in ztl null mutants; namely, lengthened circadian period, altered expression of core oscillator genes, and limited degradation of TOC1. In addition, treatment of seedlings with exogenous auxin did not alter TOC1 stability. These results demonstrate that CUL1 is required for TOC1 degradation and further suggest that this protein is the functional cullin for the SCF(ZTL) complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.