ArticlePLoS biology2008
A microtubule interactome: complexes with roles in cell cycle and mitosis.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 112 citations in OpenAlex.
- A novel MAP kinase-interacting protein MoSmi1 regulates development and pathogenicity in Magnaporthe oryzae.Molecular plant pathology · 2024Article
- Microtubule association of TRIM3 revealed by differential extraction proteomics.Journal of cell science · 2024Article
- Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division.Cellular and molecular life sciences : CMLS · 2023Review
- Long-Term Memory Formation inCells · 2023Article
- How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022Review
- The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin.PLoS genetics · 2022Article
- TEM Imaging of Membrane Choreography During Mitosis of Drosophila Tissue Culture Cells.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.Journal of cell science · 2021Article
- Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.The EMBO journal · 2020Article
- Article
- Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis.Frontiers in physiology · 2020Review
- Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium(ii) polypyridyl complex.Chemical science · 2019Article
- KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle.Life science alliance · 2019Article
- Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.eLife · 2018Article
- Ultrastructural analysis of mitotic Drosophila S2 cells identifies distinctive microtubule and intracellular membrane behaviors.BMC biology · 2018Article
- Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster.BMC developmental biology · 2018Review
- Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays.Scientific reports · 2018Article
- Novel sub-cellular localizations and intra-molecular interactions may define new functions of Mixed Lineage Leukemia protein.Cell cycle (Georgetown, Tex.) · 2018Article
- Maternal loading of a small heat shock protein increases embryo thermal tolerance inThe Journal of experimental biology · 2017Article
- RNAi-Mediated Reverse Genetic Screen IdentifiedG3 (Bethesda, Md.) · 2017Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and altering their properties. We have used a MT cosedimentation assay, combined with 1D and 2D PAGE and mass spectrometry, to identify over 250 MAPs from early Drosophila embryos. We have taken two complementary approaches to analyse the cellular function of novel MAPs isolated using this approach. First, we have carried out an RNA interference (RNAi) screen, identifying 21 previously uncharacterised genes involved in MT organisation. Second, we have undertaken a bioinformatics analysis based on binary protein interaction data to produce putative interaction networks of MAPs. By combining both approaches, we have identified and validated MAP complexes with potentially important roles in cell cycle regulation and mitosis. This study therefore demonstrates that biologically relevant data can be harvested using such a multidisciplinary approach, and identifies new MAPs, many of which appear to be important in cell division.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.