ArticleKidney international2008
Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.
Article in Kidney international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes.Frontiers in clinical diabetes and healthcare · 2026Review
- Age and Sex-related Chromogranin A Gene Polymorphisms and its Association with Metabolic Syndrome Components.Journal of the ASEAN Federation of Endocrine Societies · 2024Article
- Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis.Cellular and molecular life sciences : CMLS · 2023Review
- Chromogranin A pathway: from pathogenic molecule to renal disease.Journal of hypertension · 2020Article
- A haplotype variant of the human chromogranin A gene (The Journal of biological chemistry · 2017Article
- Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models.Journal of hypertension · 2016Article
- MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.Human molecular genetics · 2013Article
- Adrenergic genetic mechanisms in hypertension and hypertensive kidney disease.Electrolyte & blood pressure : E & BP · 2013Article
- Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins.American journal of hypertension · 2012Article
- Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.PloS one · 2012Article
- The extended granin family: structure, function, and biomedical implications.Endocrine reviews · 2011Review
- Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype.Circulation. Cardiovascular genetics · 2011Article
- Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension.Current hypertension reports · 2011Article
- Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.Cellular and molecular neurobiology · 2010Article
- Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene.Circulation. Cardiovascular genetics · 2010Article
- Chromogranin a and the autonomic system: decomposition of heart rate variability and rescue by its catestatin fragment.Endocrinology · 2010Article
- Genome-wide case/control studies in hypertension: only the 'tip of the iceberg'.Journal of hypertension · 2010Article
- Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout.Physiological genomics · 2010Article
- Chromogranin A: a novel susceptibility gene for essential hypertension.Cellular and molecular life sciences : CMLS · 2010Review
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons. We had previously identified common genetic variants at the CHGA locus in several human populations. Here we focus on whether inter-individual variants in the promoter region are of physiological significance. A common haplotype, CGATA (Hap-B), blunted the blood pressure response to cold stress and the effect exhibited molecular heterosis with the greatest blood pressure change found in Hap-A/Hap-B heterozygotes. Homozygosity for three minor alleles with peak effects within the haplotype predicted lower stress-induced blood pressure changes. The G-462A variant predicted resting blood pressure in the population with higher pressures occurring in heterozygotes (heterosis). Using cells transfected with CHGA promoter-luciferase reporter constructs, the Hap-B haplotype had decreased luciferase expression compared to the TTGTC (Hap-A) haplotype under both basal conditions and after activation by pre-ganglionic stimuli. The G-462A variant altered a COUP-TF transcriptional control motif. The two alleles in transfected promoters differed in basal activity and in the responses to COUP-II-TF transactivation and to retinoic acid. In vitro findings of molecular heterosis were also noted with the transfected CHGA promoter wherein the diploid combination of the two G-462A alleles gave rise to higher luciferase expression than either allele in isolation. Our results suggest that common genetic variants in the CHGA promoter may regulate heritable changes in blood pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.