Evidence map›Paper›PMID 18431645›Full record

ArticleDigestive diseases and sciences2008

Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.

Debashish Banerjee, Sayanti Bhattacharya, Sandip K Bandyopadhyay, Subrata Chattopadhyay

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Debashish BanerjeeDepartment of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences, Kolkata, 700 020, India.
Sayanti Bhattacharya
Sandip K Bandyopadhyay
Subrata Chattopadhyay
Bhabha Atomic Research Centre · INBose Institute · INInstitute of Basic Medical Sciences of the Chinese Academy of Medical SciencesInstitute of Post Graduate Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels. Treatment with the phytochemical allylpyrocatechol (5 mg/kg, p.o. for 3 days) provided significant ulcer healing by reversing these biochemical parameters, as well as increasing the EGF expression more than that observed due to ulceration. Omeprazole (3 mg/kg, p.o. for 3 days) provided a similar healing by improving TAS and mucin levels, without significantly altering the other parameters.

Indexed as

AnimalsAntioxidantsAnti-Ulcer AgentsCatecholsCyclooxygenase 1Cyclooxygenase 2DinoprostoneDisease Models, AnimalDose-Response Relationship, DrugIndomethacinMaleMiceOmeprazoleOxidative StressPlant ExtractsStomach UlcerallylpyrocatecholAntioxidantsAnti-Ulcer AgentsCatecholsCyclooxygenase 1Cyclooxygenase 2DinoprostoneIndomethacinOmeprazolePlant ExtractsVascular Endothelial Growth Factor Avon Willebrand Factor

Identifiers

PMID18431645
OpenAlexW2125730401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.