ArticleThe Journal of clinical investigation2008
What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Contribution of interaction between genetic variants of interleukin-11 andOncoTargets and therapy · 2019Article
- From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.Cell communication and signaling : CCS · 2017Review
- Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike.World journal of gastrointestinal oncology · 2016Review
- Autoimmunity as a double agent in tumor killing and cancer promotion.Frontiers in immunology · 2014Review
- Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway.Medical oncology (Northwood, London, England) · 2013Article
- Genetic aspects of gastric cancer instability.TheScientificWorldJournal · 2012Review
- Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.International journal of biological sciences · 2012Article
- Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.The Journal of clinical investigation · 2011Article
- Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.Neoplasia (New York, N.Y.) · 2011Article
- Expression of anion exchanger 1 is associated with tumor progress in human gastric cancer.Journal of cancer research and clinical oncology · 2009Article
- Hepatitis C virus core protein augments androgen receptor-mediated signaling.Journal of virology · 2008Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chronic inflammation in the stomach induces cellular transformation and gastric cancer primarily in the distal stomach or antrum. In this issue of the JCI, a study in mice by Ernst et al. provides new insight into the role of IL-11 and its glycoprotein 130 (gp130) receptor in inflammation-associated gastric epithelial cell oncogenic transformation, which they show is mediated by and dependent on increased activation of Stat3 and, to a lesser extent, Stat1 (see the related article beginning on page 1727). Prior studies from this group have shown that Stat3 hyperactivity stimulates the TGF-beta inhibitor Smad7. Collectively, the studies suggest that an important pathway of oncogenic transformation in the stomach is through suppression of growth inhibitory signals, such as members of the TGF-beta family, that originate from the stroma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.