ArticleJournal of the American Society of Hypertension : JASH2007
Overweight and Hyperinsulinemia Provide Individual Contributions to Compromises in Brachial Artery Distensibility in Healthy Adolescents and Young Adults: Brachial Distensibility in Children.
Article in Journal of the American Society of Hypertension : JASH, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Effect of vitamin D3 treatment on endothelial function in obese adolescents.Pediatric obesity · 2016Trial
- Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan.Nutrients · 2021Review
- Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.Pediatric diabetes · 2020Article
- Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output.Hypertension in pregnancy · 2018Article
- Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes.Current diabetes reports · 2016Review
- Impact of childhood obesity on cardiac structure and function.Current treatment options in cardiovascular medicine · 2014Article
- Obesity, metabolic syndrome, and insulin resistance in urban high school students of minority race/ethnicity.Archives of pediatrics & adolescent medicine · 2012Article
- Insulin resistance and arterial stiffness in healthy adolescents and young adults.Diabetologia · 2012Article
- Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus.Journal of hypertension · 2010Article
- Association of adiposity with pulse pressure amongst gujarati Indian adolescents.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2010Article
- Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults.International journal of obesity (2005) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBrachial artery distensibility (BrachD) was measured in healthy children to identify associations with atherosclerotic risk factors.
methods969 black and white subjects 13-22 years were classified as lean (L) or overweight (O) and hyperinsulinemic (H-I) or normoinsulinemic (N-I). BP and BrachD were obtained with a DynaPulse Pathway instrument. ANOVA was performed looking for group mean differences. Correlations between BrachD and risk variables were examined. Determinates of BrachD were determined by backward elimination regression stratified by BMI-Insulin group.
resultsDecreased BrachD correlated with male gender, O, higher BP, HR, fasting glucose and log of fasting insulin after adjusting for pulse pressure (PP). BrachD was greatest in L/N-I with progressive decreases seen in L/H-I, O/N-I, and O/H-I subjects. Regression modeling found PP and HR were major determinates of BrachD. Glucose was significant for subjects with N-I regardless of adiposity. Excluding BP, glucose remained important in N-I subjects. Gender was significant for all. HR retained significance only in O subjects regardless of insulin level.
conclusionsIn healthy adolescents, hyperinsulinemia and obesity adversely affect brachial artery function with overweight contributing to a greater degree. In normoinsulinemic subjects, fasting glucose was inversely related to BrachD. Metabolic factors may play a role in vascular function in youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.