ArticleGenetics2008
Exploring population genetic models with recombination using efficient forward-time simulations.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Polygenic selection to a changing optimum under self-fertilisation.PLoS genetics · 2024Article
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- Subspecies divergence and pronounced phylogenetic incongruence in the East-Asia-endemic shrub Magnolia sieboldii.Annals of botany · 2021Article
- Efficient pedigree recording for fast population genetics simulation.PLoS computational biology · 2018Article
- Selecting among Alternative Scenarios of Human Evolution by Simulated Genetic Gradients.Genes · 2018Review
- Article
- Limits to Adaptation in Partially Selfing Species.Genetics · 2016Article
- Background Selection in Partially Selfing Populations.Genetics · 2016Article
- A C++ template library for efficient forward-time population genetic simulation of large populations.Genetics · 2014Article
- Spatial and temporal simulation of human evolution. Methods, frameworks and applications.Current genomics · 2014Article
- Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario.G3 (Bethesda, Md.) · 2014Article
- forqs: forward-in-time simulation of recombination, quantitative traits and selection.Bioinformatics (Oxford, England) · 2014Article
- SLiM: simulating evolution with selection and linkage.Genetics · 2013Article
- Rapid forward-in-time simulation at the chromosome and genome level.BMC bioinformatics · 2013Article
- Boosting forward-time population genetic simulators through genotype compression.BMC bioinformatics · 2013Article
- Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.PLoS genetics · 2013Article
- Computer programs and methodologies for the simulation of DNA sequence data with recombination.Frontiers in genetics · 2013Article
- Simulation of molecular data under diverse evolutionary scenarios.PLoS computational biology · 2012Article
- Computer simulations: tools for population and evolutionary genetics.Nature reviews. Genetics · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present an exact forward-in-time algorithm that can efficiently simulate the evolution of a finite population under the Wright-Fisher model. We used simulations based on this algorithm to verify the accuracy of the ancestral recombination graph approximation by comparing it to the exact Wright-Fisher scenario. We find that the recombination graph is generally a very good approximation for models with complete outcrossing, whereas, for models with self-fertilization, the approximation becomes slightly inexact for some combinations of selfing and recombination parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.