ArticleGenetics2008
Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- Regionally specific and highly pleiotropic loci together mediate skeletal evolution in tropical and temperate house mice.Genetics · 2026Article
- Patterns and evolutionary consequences of pleiotropy.Annual review of ecology, evolution, and systematics · 2023Article
- The genetic basis of neurocranial size and shape across varied lab mouse populations.Journal of anatomy · 2022Article
- A complex genetic architecture underlies mandibular evolution in big mice from Gough Island.Genetics · 2022Article
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- The obstetrical dilemma hypothesis: there's life in the old dog yet.Biological reviews of the Cambridge Philosophical Society · 2021Article
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- Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.Cell metabolism · 2019Article
- Sex differences in metabolism and cardiometabolic disorders.Current opinion in lipidology · 2018Review
- Evolutionary trade-offs and the structure of polymorphisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring.PloS one · 2018Article
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- The evolution of phenotypic integration: How directional selection reshapes covariation in mice.Evolution; international journal of organic evolution · 2017Article
- The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.G3 (Bethesda, Md.) · 2017Article
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- Directional selection can drive the evolution of modularity in complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.Frontiers in physiology · 2015Article
- Modular skeletal evolution in sticklebacks is controlled by additive and clustered quantitative trait Loci.Genetics · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Quantitative trait locus (QTL) studies of a skeletal trait or a few related skeletal components are becoming commonplace, but as yet there has been no investigation of pleiotropic patterns throughout the skeleton. We present a comprehensive survey of pleiotropic patterns affecting mouse skeletal morphology in an intercross of LG/J and SM/J inbred strains (N = 1040), using QTL analysis on 70 skeletal traits. We identify 798 single-trait QTL, coalescing to 105 loci that affect on average 7-8 traits each. The number of traits affected per locus ranges from only 1 trait to 30 traits. Individual traits average 11 QTL each, ranging from 4 to 20. Skeletal traits are affected by many, small-effect loci. Significant additive genotypic values average 0.23 standard deviation (SD) units. Fifty percent of loci show codominance with heterozygotes having intermediate phenotypic values. When dominance does occur, the LG/J allele tends to be dominant to the SM/J allele (30% vs. 8%). Over- and underdominance are relatively rare (12%). Approximately one-fifth of QTL are sex specific, including many for pelvic traits. Evaluating the pleiotropic relationships of skeletal traits is important in understanding the role of genetic variation in the growth and development of the skeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.