ArticleGenetics2008
Genetic variation affecting host-parasite interactions: different genes affect different aspects of sigma virus replication and transmission in Drosophila melanogaster.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater.Evolution letters · 2025Article
- Crop diversity induces trade-offs in microbial biopesticide susceptibility that could delay pest resistance evolution.PLoS pathogens · 2025Article
- Article
- Local adaptation at higher trophic levels: contrasting hyperparasite-pathogen infection dynamics in the field and laboratory.Molecular ecology · 2017Article
- The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.PLoS biology · 2015Article
- Host adaptation to viruses relies on few genes with different cross-resistance properties.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Viruses and antiviral immunity in Drosophila.Developmental and comparative immunology · 2014Review
- The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?BMC biology · 2013Review
- Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone?Proceedings. Biological sciences · 2012Article
- Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep.Genetics · 2011Article
- The prevalence and persistence of sigma virus, a biparentally transmitted parasite ofEvolutionary ecology research · 2011Article
- Disease association mapping in Drosophila can be replicated in the wild.Biology letters · 2010Article
- Drosophila as a model for antiviral immunity.World journal of biological chemistry · 2010Article
- Article
- The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae).PloS one · 2009Article
- Introduction. Ecological immunology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In natural populations, genetic variation affects resistance to disease. Knowing how much variation exists, and understanding the genetic architecture of this variation, is important for medicine, for agriculture, and for understanding evolutionary processes. To investigate the extent and nature of genetic variation affecting resistance to pathogens, we are studying a tractable model system: Drosophila melanogaster and its natural pathogen the vertically transmitted sigma virus. We show that considerable genetic variation affects transmission of the virus from parent to offspring. However, maternal and paternal transmission of the virus is affected by different genes. Maternal transmission is a simple Mendelian trait: most of the genetic variation is explained by a polymorphism in ref(2)P, a gene already well known to affect resistance to sigma. In contrast, there is considerable genetic variation in paternal transmission that cannot be explained by ref(2)P and is caused by other loci on chromosome 2. Furthermore, we found no genetic correlation between paternal transmission of the virus and resistance to infection by the sigma virus following injection. This suggests that different loci affect viral replication and paternal transmission.
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