ArticleGenetics2008
The rate and spectrum of microsatellite mutation in Caenorhabditis elegans and Daphnia pulex.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- The evolution of tandem repeat sequences under partial selfing and different modes of selection.Heredity · 2026Article
- Fitness landscapes of human microsatellites.PLoS genetics · 2024Article
- Time-resolved, integrated analysis of clonally evolving genomes.PLoS genetics · 2023Article
- Adaptive phenotypic plasticity is under stabilizing selection in Daphnia.Nature ecology & evolution · 2022Article
- Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle.PLoS neglected tropical diseases · 2022Article
- Genome-wide characterization of microsatellite DNA in fishes: survey and analysis of their abundance and frequency in genome-specific regions.BMC genomics · 2021Article
- Recent demographic histories of temperate deciduous trees inferred from microsatellite markers.BMC ecology and evolution · 2021Article
- Population connectivity, dispersal, and swimming behavior inEcology and evolution · 2021Article
- Intraspecific Variation in Microsatellite Mutation Profiles in Daphnia magna.Molecular biology and evolution · 2019Article
- Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.Ecology and evolution · 2019Article
- Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment.Genome biology and evolution · 2019Article
- Evolution of the Mutational Process under Relaxed Selection in Caenorhabditis elegans.Molecular biology and evolution · 2019Article
- Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii.Genome biology and evolution · 2018Article
- Development of polymorphic EST microsatellite markers for the sand fly, Phlebotomus papatasi (Diptera: Psychodidae).Parasites & vectors · 2018Article
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- Temporal sampling helps unravel the genetic structure of naturally occurring populations of a phytoparasitic nematode. 2. Separating the relative effects of gene flow and genetic drift.Evolutionary applications · 2016Article
- Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes.PLoS genetics · 2015Article
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- Opposing forces of A/T-biased mutations and G/C-biased gene conversions shape the genome of the nematode Pristionchus pacificus.Genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The effective use of microsatellite loci as tools for microevolutionary analysis requires knowledge of the factors influencing the rate and pattern of mutation, much of which is derived from indirect inference from population samples. Interspecific variation in microsatellite stability also provides a glimpse into aspects of phylogenetic constancy of mutational processes. Using long-term series of mutation-accumulation lines, we have obtained direct estimates of the spectrum of microsatellite mutations in two model systems: the nematode Caenorhabditis elegans and the microcrustacean Daphnia pulex. Although the scaling of the mutation rate with the number of tandem repeats is highly consistent across distantly related species, including yeast and human, the per-cell-division mutation rate appears to be elevated in multicellular species. Contrary to the expectations under the stepwise mutation model, most microsatellite mutations in C. elegans and D. pulex involve changes of multiple repeat units, with expansions being much more common than contractions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.