ArticleGenetics2008
Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila.Cancers · 2021Review
- Reproductive consequences of an extra long-term sperm storage organ.BMC evolutionary biology · 2020Article
- Finding a place and leaving a mark in memory formation.Journal of neurogenetics · 2020Review
- The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation.Neurobiology of learning and memory · 2017Article
- Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2015Review
- Structured inquiry-based learning: Drosophila GAL4 enhancer trap characterization in an undergraduate laboratory course.PLoS biology · 2014Article
- Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways.Scientifica · 2013Article
- Drosophila melanogaster as a model to study drug addiction.Human genetics · 2012Review
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- A Drosophila model for alcohol reward.Nature neuroscience · 2011Article
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- Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.PloS one · 2010Article
- Short-term memories in Drosophila are governed by general and specific genetic systems.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Review
- Place memory formation in Drosophila is independent of proper octopamine signaling.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
- The genetics of behavioral alcohol responses in Drosophila.International review of neurobiology · 2010Review
- An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance.Alcoholism, clinical and experimental research · 2009Article
- Rapid matching in Drosophila place learning.Die Naturwissenschaften · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of these have increased ethanol sensitivity, and the other 5 do not. We tested place and olfactory memory in each of these lines and found two new learning mutations. In one case, altering the tribbles gene, flies have a significantly reduced place memory, elevated olfactory memory, and normal ethanol response. In the second case, mutation of a gene we name ethanol sensitive with low memory (elm), place memory was not altered, olfactory memory was sharply reduced, and sensitivity to ethanol was increased. In sum, however, we found no overall correlation between ethanol sensitivity and place memory in the 10 lines tested. Furthermore, there was a weak but nonsignificant correlation between ethanol sensitivity and olfactory learning. Thus, mutations that alter learning and sensitivity to ethanol can occur independently of each other and this implies that the set of genes important for both ethanol sensitivity and learning is likely a subset of the genes important for either process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.