ArticleGenetics2008
The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesis.Journal of virology · 2026Article
- Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity.bioRxiv : the preprint server for biology · 2025Article
- Caenorhabditis elegans germ granules are present in distinct configurations and assemble in a hierarchical manner.Development (Cambridge, England) · 2023Article
- Review
- Article
- Transgene-Assisted Genetic Screen IdentifiesJournal of virology · 2018Article
- Movement of regulatory RNA between animal cells.Genesis (New York, N.Y. : 2000) · 2015Review
- Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.EMBO reports · 2015Article
- Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Antiviral RNA silencing initiated in the absence of RDE-4, a double-stranded RNA binding protein, in Caenorhabditis elegans.Journal of virology · 2013Article
- Characterization of virus-encoded RNA interference suppressors in Caenorhabditis elegans.Journal of virology · 2013Article
- SID-5 is an endosome-associated protein required for efficient systemic RNAi in C. elegans.Current biology : CB · 2012Article
- New insights into siRNA amplification and RNAi.RNA biology · 2012Article
- Article
- The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.Current biology : CB · 2012Article
- Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
In Caenorhabditis elegans, exogenous dsRNA can elicit systemic RNAi, a process that requires the function of many genes. Considering that the activities of many of these genes are also required for normal development, it is surprising that exposure to high concentrations of dsRNA does not elicit adverse consequences to animals. Here, we report inducible phenotypes in attenuated C. elegans strains reared in environments that include nonspecific dsRNA and elevated temperature. Under these conditions, chromosome integrity is compromised in RNAi-defective strains harboring mutations in rsd-2 or rsd-6. Specifically, rsd-2 mutants display defects in transposon silencing, while meiotic chromosome disjunction is affected in rsd-6 mutants. RSD-2 proteins localize to multiple cellular compartments, including the nucleolus and cytoplasmic compartments that, in part, are congruent with calreticulin and HAF-6. We considered that the RNAi defects in rsd-2 mutants might have relevance to membrane-associated functions; however, endomembrane compartmentalization and endocytosis/exocytosis markers in rsd-2 and rsd-6 mutants appear normal. The mutants also possess environmentally sensitive defects in cell-autonomous RNAi elicited from transgene-delivered dsRNAs. Thus, the ultimate functions of rsd-2 and rsd-6 in systemic RNAi are remarkably complex and environmentally responsive.
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