ArticleGenetics2008
A Mutator transposon insertion is associated with ectopic expression of a tandemly repeated multicopy Myb gene pericarp color1 of maize.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Independent evolution of transposase and TIRs facilitated by recombination betweenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A novel maize dwarf mutant generated by Ty1-copia LTR-retrotransposon insertion in Brachytic2 after spaceflight.Plant cell reports · 2020Article
- A maize polygalacturonase functions as a suppressor of programmed cell death in plants.BMC plant biology · 2019Article
- Altered nucleosome positions in maize haplotypes and mutants of a subset of SWI/SNF-like proteins.Plant direct · 2017Article
- KRN4 Controls Quantitative Variation in Maize Kernel Row Number.PLoS genetics · 2015Article
- Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.Molecular therapy. Nucleic acids · 2014Article
- Characterization of OsMIK in a rice mutant with reduced phytate content reveals an insertion of a rearranged retrotransposon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Functional analysis of the HS185 regulatory element in the rice HSP70 promoter.Molecular biology reports · 2012Article
- Pack-MULEs: Recycling and reshaping genes through GC-biased acquisition.Mobile genetic elements · 2011Article
- Pack-Mutator-like transposable elements (Pack-MULEs) induce directional modification of genes through biased insertion and DNA acquisition.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Tissue culture-induced novel epialleles of a Myb transcription factor encoded by pericarp color1 in maize.Genetics · 2010Article
- Genetic perspectives on crop domestication.Trends in plant science · 2010Review
- Gene structure induced epigenetic modifications of pericarp color1 alleles of maize result in tissue-specific mosaicism.PloS one · 2009Article
- Stable transcription activities dependent on an orientation of Tam3 transposon insertions into Antirrhinum and yeast promoters occur only within chromatin.Plant physiology · 2009Article
- Progressive loss of DNA methylation releases epigenetic gene silencing from a tandemly repeated maize Myb gene.Genetics · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular basis of tissue-specific pigmentation of maize carrying a tandemly repeated multicopy allele of pericarp color1 (p1) was examined using Mutator (Mu) transposon-mediated mutagenesis. The P1-wr allele conditions a white or colorless pericarp and a red cob glumes phenotype. However, a Mu-insertion allele, designated as P1-wr-mum6, displayed an altered phenotype that was first noted as occasional red stripes on pericarp tissue. This gain-of-pericarp-pigmentation phenotype was heritable, yielding families that displayed variable penetrance and expressivity. In one fully penetrant family, deep red pericarp pigmentation was observed. Several reports on Mu suppressible alleles have shown that Mu transposons can affect gene expression by mechanisms that depend on transposase activity. Conversely, the P1-wr-mum6 phenotype is not affected by transposase activity. The increased pigmentation was associated with elevated mRNA expression of P1-wr-mum6 copy (or copies) that was uninterrupted by the transposons. Genomic bisulfite sequencing analysis showed that the elevated expression was associated with hypomethylation of a floral-specific enhancer that is approximately 4.7 kb upstream of the Mu1 insertion site and may be proximal to an adjacent repeated copy. We propose that the Mu1 insertion interferes with the DNA methylation and related chromatin packaging of P1-wr, thereby inducing expression from gene copy (or copies) that is otherwise suppressed.
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