ArticlePhysiological genomics2008
Physiological and molecular evidence of heat acclimation memory: a lesson from thermal responses and ischemic cross-tolerance in the heart.
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Heat Acclimation Decay and Re-Induction: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Dynamic responses in the human methylome to exertional heat exhaustion, heat injury, and heat stroke.Human genomics · 2026Article
- Review
- Influence of extreme heat waves as an aggravating factor in the cause of death from cardiovascular diseases in Southeast Brazil.Cadernos de saude publica · 2026Article
- Long-term epigenetic and metabolomic changes in the mouse ventricular myocardium after exertional heat stroke.Physiological genomics · 2022Article
- Epigenetic responses to heat: From adaptation to maladaptation.Experimental physiology · 2022Review
- Sweat rate and sweat composition following active or passive heat re-acclimation: A pilot study.Temperature (Austin, Tex.) · 2020Article
- The emergence of heat and humidity too severe for human tolerance.Science advances · 2020Article
- Application of evidence-based recommendations for heat acclimation: Individual and team sport perspectives.Temperature (Austin, Tex.) · 2019Review
- Circular RNA Expression Profiling and Selection of Key Circular RNAs in the Hypothalamus of Heat-Acclimated Rats.Frontiers in physiology · 2019Article
- Long-term HIF-1α transcriptional activation is essential for heat-acclimation-mediated cross tolerance: mitochondrial target genes.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Heat Acclimation-Mediated Cross-Tolerance: Origins in within-Life Epigenetics?Frontiers in physiology · 2017Review
- Role of dynamin-related protein 1-mediated mitochondrial fission in resistance of mouse C2C12 myoblasts to heat injury.The Journal of physiology · 2016Article
- Cross Acclimation between Heat and Hypoxia: Heat Acclimation Improves Cellular Tolerance and Exercise Performance in Acute Normobaric Hypoxia.Frontiers in physiology · 2016Article
- Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms.Frontiers in neuroscience · 2015Review
- Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Heat acclimation decreased oxidative DNA damage resulting from exposure to high heat in an occupational setting.European journal of applied physiology · 2012Article
- Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging.Molecular imaging · 2012Article
- Regulation of survival gene hsp70.Cell stress & chaperones · 2012Review
- Heat exposure does not alter eccentric exercise-induced increases in mitochondrial calcium and respiratory dysfunction.European journal of applied physiology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Sporadic findings in humans suggest that reinduction of heat acclimation (AC) after its loss occurs markedly faster than that during the initial AC session. Animal studies substantiated that the underlying acclimatory processes are molecular. Here we test the hypothesis that faster reinduction of AC (ReAC) implicates "molecular memory." In vivo measurements of colonic temperature profiles during heat stress and ex vivo assessment of cross-tolerance to ischemia-reperfusion or anoxia insults in the heart demonstrated that ReAC only needs 2 days vs. the 30 days required for the initial development of AC. Stress gene profiling in the experimental groups highlighted clusters of transcriptionally activated genes (37%), which included heat shock protein (HSP) genes, antiapoptotic genes, and chromatin remodeling genes. Despite a return of the physiological phenotype to its preacclimation state, after a 1 mo deacclimation (DeAC) period, the gene transcripts did not resume their preacclimation levels, suggesting a dichotomy between genotype and phenotype in this system. Individual detection of hsp70 and hsf1 transcripts agreed with these findings. HSP72, HSF1/P-HSF1, and Bcl-xL protein profiles followed the observed dichotomized genomic response. In contrast, HSP90, an essential cytoprotective component mismatched transcriptional activation upon DeAC. The uniform activation of the similarly responding gene clusters upon De-/ReAC implies that reacclimatory phenotypic plasticity is associated with upstream denominators. During AC, DeAC, and ReAC, the maintenance of elevated/phosphorylated HSF1 protein levels and transcriptionally active chromatin remodeling genes implies that chromatin remodeling plays a pivotal role in the transcriptome profile and in preconditioning to rapid cytoprotective acclimatory memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.