Evidence map›Paper›PMID 18430399›Full record

ReviewCurrent osteoporosis reports2008

Treatment of premenopausal women with low bone mineral density.

Adi Cohen, Elizabeth Shane

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study.The Journal of clinical endocrinology and metabolism · 2013
    Trial
  3. Article
  4. U.S. Medical Eligibility Criteria for Contraceptive Use, 2024.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Premenopausal bone health: osteoporosis in premenopausal women.Clinical obstetrics and gynecology · 2013
    Review
  9. Article
  10. Osteoporosis in young adults: pathophysiology, diagnosis, and management.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Review
  11. Article
  12. Gender aspects of osteoporosis and bone strength.Wiener medizinische Wochenschrift (1946) · 2011
    Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Adi CohenColumbia University, College of Physicians and Surgeons, Department of Medicine, PH8-864, 630 West 168th Street, New York, NY 10032, USA. ac1044@columbia.edu
Elizabeth Shane

Funding

Idiopathic Osteoporosis in Premenopausal WomenK24AR052665 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$1.8M
Bone Quality in Premenopausal Women with Idiopathic Fragility FracturesK23AR054127 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COHEN, ADI · 2007 to 2011
$642k
NIAMS NIH HHS K23 AR054127NIAMS NIH HHS K24 AR052665
6 · The paper itself

Abstract

Interpretation of bone mineral density (BMD) results in premenopausal women is particularly challenging, because the relationship between BMD and fracture risk is not the same as for postmenopausal women. Z scores rather than T scores should be used to define "low BMD" in premenopausal women. The finding of low BMD in a premenopausal woman should prompt an evaluation for secondary causes of bone loss. If a secondary cause is found, management should focus on treatment of this condition. In some cases in which the secondary cause cannot be addressed, such as glucocorticoid therapy or cancer chemotherapy, treatment with a bone-active agent to prevent bone loss should be considered. In women with no fractures and no known secondary cause, low BMD may not signify compromised bone strength. BMD is likely to remain stable in these women, and pharmacologic therapy is rarely justified. Assessment of markers of bone turnover and follow-up bone density measurements can help to identify those with an ongoing process of bone loss that may indicate a higher risk for fracture, and possible need for pharmacologic intervention.

Indexed as

Bone DensityBone Density Conservation AgentsDiagnosis, DifferentialDiphosphonatesFemaleHumansOsteoporosisPremenopauseTeriparatideBone Density Conservation AgentsDiphosphonatesTeriparatide

Identifiers

PMID18430399
PMCPMC4414067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.