ArticleBMC psychiatry2008
ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents.
Article in BMC psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Subthreshold attention deficit hyperactivity in children and adolescents: a systematic review.European child & adolescent psychiatry · 2014Pooled it
- Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025Review
- Connection Failure: Differences in White Matter Microstructure Are Associated withInternational journal of molecular sciences · 2024Article
- Association between platelet MAO activity and lifetime drug use in a longitudinal birth cohort study.Psychopharmacology · 2022Article
- Parenting and Sibling Relationships in Family with Disruptive Behavior Disorders. Are Non-Clinical Siblings More Vulnerable for Emotional and Behavioral Problems?Brain sciences · 2021Article
- Predictors of Alcohol Use Disorder: MAOA Gene VNTR Polymorphism, Impulsivity, and Personality Traits.Psychiatry and clinical psychopharmacology · 2021Article
- Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males.Biomolecules · 2020Article
- Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?Frontiers in neuroscience · 2020Article
- A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder.Child development · 2018Article
- Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands.BMC medical genetics · 2017Article
- Psychopathic traits mediate the association of serotonin transporter genotype and child externalizing behavior.Aggressive behavior · 2016Article
- Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Potential contribution of monoamine oxidase a gene variants in ADHD and behavioral co-morbidities: scenario in eastern Indian probands.Neurochemical research · 2014Article
- Low dopamine function in attention deficit/hyperactivity disorder: should genotyping signify early diagnosis in children?Postgraduate medicine · 2014Review
- Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study.Behavioral and brain functions : BBF · 2011Article
- Is the severity of adolescent conduct disorder associated with the level of nicotine dependence?European child & adolescent psychiatry · 2011Article
- Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies.Journal of abnormal child psychology · 2011Article
- A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.Biological psychiatry · 2011Article
- Platelet monoamine oxidase activity predicts alcohol sensitivity and voluntary alcohol intake in rhesus monkeys.Upsala journal of medical sciences · 2010Article
- Constitutional mechanisms of vulnerability and resilience to nicotine dependence.Molecular psychiatry · 2009Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD) and Disruptive Behavior Disorder (DBD). We have, in a population-based sample, studied associations between dimensions of the ADHD/DBD phenotype and Monoamine Oxidase B (MAO-B) activity in platelets and polymorphisms in two serotonergic genes: the Monoamine Oxidase A Variable Number of Tandem Repeats (MAO-A VNTR) and the 5-Hydroxytryptamine Transporter gene-Linked Polymorphic Region (5-HTT LPR).
methodsA population-based sample of twins, with an average age of 16 years, was assessed for ADHD/DBD with a clinical interview; Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). Blood was drawn from 247 subjects and analyzed for platelet MAO-B activity and polymorphisms in the MAO-A and 5-HTT genes.
resultsWe found an association in girls between low platelet MAO-B activity and symptoms of Oppositional Defiant Disorder (ODD). In girls, there was also an association between the heterozygote long/short 5-HTT LPR genotype and symptoms of conduct disorder. Furthermore the heterozygote 5-HTT LPR genotype in boys was found to be associated with symptoms of Conduct Disorder (CD). In boys, hemizygosity for the short MAO-A VNTR allele was associated with disruptive behavior.
conclusionOur study suggests that the serotonin system, in addition to the dopamine system, should be further investigated when studying genetic influences on the development of Disruptive Behavior Disorders.
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