ArticleBMC developmental biology2008
Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanosensation and Mechanotransduction by Lymphatic Endothelial Cells Act as Important Regulators of Lymphatic Development and Function.International journal of molecular sciences · 2021Review
- Absence of lymphatic vessels in term placenta.BMC pregnancy and childbirth · 2020Article
- Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors.Journal of leukocyte biology · 2017Review
- Host immune cellular reactions in corneal neovascularization.International journal of ophthalmology · 2016Review
- High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation.Frontiers in immunology · 2016Review
- Molecular underpinnings of corneal angiogenesis: advances over the past decade.International journal of ophthalmology · 2016Review
- Article
- Lymphatic vessels and tertiary lymphoid organs.The Journal of clinical investigation · 2014Review
- Lymphangiogenesis and angiogenesis during human fetal pancreas development.Vascular cell · 2014Article
- Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis.Vascular cell · 2012Article
- Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors.Cancers · 2012Article
- Myeloid cells and lymphangiogenesis.Cold Spring Harbor perspectives in medicine · 2012Review
- Article
- Formation of cardiovascular tubes in invertebrates and vertebrates.Cellular and molecular life sciences : CMLS · 2010Review
- Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice.Development (Cambridge, England) · 2010Article
- Lymphatic development.Birth defects research. Part C, Embryo today : reviews · 2009Review
- Developmental and pathological lymphangiogenesis: from models to human disease.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe data on the embryonic origin of lymphatic endothelial cells (LECs) from either deep embryonic veins or mesenchymal (or circulating) lymphangioblasts presently available remain inconsistent. In various vertebrates, markers for LECs are first expressed in specific segments of embryonic veins arguing for a venous origin of lymph vessels. Very recently, studies on the mouse have strongly supported this view. However, in the chick, we have observed a dual origin of LECs from veins and from mesodermal lymphangioblasts. Additionally, in murine embryos we have detected mesenchymal cells that co-express LEC markers and the pan-leukocyte marker CD45. Here, we have characterized the mesoderm of murine embryos with LEC markers Prox1, Lyve-1 and LA102 in combination with macrophage markers CD11b and F4/80.
resultsWe observed cells co-expressing both types of markers (e.g. Prox1 - Lyve-1 - F4/80 triple-positive) located in the mesoderm, immediately adjacent to, and within lymph vessels. Our proliferation studies with Ki-67 antibodies showed high proliferative capacities of both the Lyve-1-positive LECs of lymph sacs/lymphatic sprouts and the Lyve-1-positive mesenchymal cells.
conclusionOur data argue for a dual origin of LECs in the mouse, although the primary source of embryonic LECs may reside in specific embryonic veins and mesenchymal lymphangioblasts integrated secondarily into lymph vessels. The impact of a dual source of LECs for ontogenetic, phylogenetic and pathological lymphangiogenesis is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.