ArticleMolecular microbiology2008
The receiver domain of FrzE, a CheA-CheY fusion protein, regulates the CheA histidine kinase activity and downstream signalling to the A- and S-motility systems of Myxococcus xanthus.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Milestones in the development ofJournal of bacteriology · 2025Review
- A cyanobacterial chemotaxis-like system controls phototactic orientation via phosphorylation of two antagonistic response regulators.microLife · 2024Article
- Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus.Scientific reports · 2019Article
- A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus.Nature microbiology · 2018Article
- Identification of two different chemosensory pathways in representatives of the genus Halomonas.BMC genomics · 2018Article
- Distinct Domains of CheA Confer Unique Functions in Chemotaxis and Cell Length in Azospirillum brasilense Sp7.Journal of bacteriology · 2017Article
- Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway.PLoS genetics · 2015Article
- Article
- Dual biochemical oscillators may control cellular reversals in Myxococcus xanthus.Biophysical journal · 2014Article
- Cell division resets polarity and motility for the bacterium Myxococcus xanthus.Journal of bacteriology · 2014Article
- Phosphorylation-dependent localization of the response regulator FrzZ signals cell reversals in Myxococcus xanthus.Molecular microbiology · 2013Article
- Phosphate flow between hybrid histidine kinases CheA₃ and CheS₃ controls Rhodospirillum centenum cyst formation.PLoS genetics · 2013Article
- Chemosensory signaling controls motility and subcellular polarity in Myxococcus xanthus.Current opinion in microbiology · 2012Review
- A response regulator interfaces between the Frz chemosensory system and the MglA/MglB GTPase/GAP module to regulate polarity in Myxococcus xanthus.PLoS genetics · 2012Article
- Intra- and interprotein phosphorylation between two-hybrid histidine kinases controls Myxococcus xanthus developmental progression.The Journal of biological chemistry · 2012Article
- A dynamic response regulator protein modulates G-protein-dependent polarity in the bacterium Myxococcus xanthus.PLoS genetics · 2012Article
- Uncovering the mystery of gliding motility in the myxobacteria.Annual review of genetics · 2011Review
- Article
- Identification of YsrT and evidence that YsrRST constitute a unique phosphorelay system in Yersinia enterocolitica.Journal of bacteriology · 2010Article
- Developments in Defining dif.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Frz chemosensory system is a two-component signal transduction pathway that controls cell reversals and directional movements for the two motility systems in Myxococcus xanthus. To trigger cell reversals, FrzE, a hybrid CheA-CheY fusion protein, autophosphorylates the kinase domain at His-49, and phosphoryl groups are transferred to aspartate residues (Asp-52 and Asp-220) in the two receiver domains of FrzZ, a dual CheY-like protein that serves as the pathway output. The role of the receiver domain of FrzE was unknown. In this paper, we characterize the FrzE protein in vitro and show that the receiver domain of FrzE negatively regulates the autophosphorylation activity of the kinase domain of FrzE. Unexpectedly, it does not appear to play a direct role in phospho-relay as in most other histidine kinase receiver domain hybrid systems. The regulatory role of the FrzE receiver domain suggests that it may interact with or be phosphorylated by an unknown protein. We also show the dynamics of motility system-specific marker proteins in FrzE mutants as cells move forward and reverse. Our studies indicate that the two motility systems are functionally co-ordinated and that any system-specific branching of the pathway most likely occurs downstream of FrzE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.