ArticleJournal of anatomy2008
Three-dimensional ontogenetic shape changes in the human cranium during the fetal period.
Article in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Computed Tomography-Based Morphometric Analysis of Ossification Centers of Lesser Wings of Sphenoid Bone in Human Fetuses.Brain sciences · 2025Article
- Quantitative study of the ossification centers of the body of sphenoid bone in the human fetus.Scientific reports · 2024Article
- Sexual dimorphism in human midfacial growth patterns from newborn to 5 years old based on computed tomography.Journal of anatomy · 2023Article
- Quantitative anatomy of the primary ossification center of the squamous part of temporal bone in the human fetus.PloS one · 2023Article
- Clinical value of fetal facial profile markers during the first trimester.BMC pregnancy and childbirth · 2022Article
- Article
- Ultrasonographic study of fetal facial profile markers during the first trimester.BMC pregnancy and childbirth · 2021Article
- Quantitative anatomy of the fused ossification center of the occipital squama in the human fetus.PloS one · 2021Article
- Three-dimensional geometric morphometric studies of modern human occipital variation.PloS one · 2021Article
- Covariation of fetal skull and maternal pelvis during the perinatal period in rhesus macaques and evolution of childbirth in primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Morphometric study of the primary ossification center of the frontal squama in the human fetus.Surgical and radiologic anatomy : SRA · 2020Article
- Maturation of the human foetal basioccipital: quantifying shape changes in second and third trimesters using elliptic Fourier analysis.Journal of anatomy · 2019Article
- Morphological variation in the anterior cranial fossa.Clinical and experimental dental research · 2019Article
- Macroanatomical Landmarks Featuring Junctions of Major Sulci and Fissures and Scalp Landmarks Based on the International 10-10 System for Analyzing Lateral Cortical Development of Infants.Frontiers in neuroscience · 2017Article
- Fetal and neonatal maxillary ontogeny in extant humans and the utility of prenatal maxillary morphology in predicting ancestral affiliation.American journal of physical anthropology · 2016Article
- Size, shape, and form: concepts of allometry in geometric morphometrics.Development genes and evolution · 2016Review
- The influence of life history and sexual dimorphism on entheseal changes in modern humans and African great apes.PloS one · 2014Article
- Cephalometric assessment of human fetal head specimens.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2013Article
- Prenatal ontogeny of subspecific variation in the craniofacial morphology of the Japanese macaque (Macaca fuscata).Primates; journal of primatology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of the pattern of human craniofacial development in the fetal period is important for understanding the mechanisms underlying the emergence of variations in human craniofacial morphology. However, the precise character of the prenatal ontogenetic development of the human cranium has yet to be fully established. This study investigates ontogenetic changes in cranial shape in the fetal period, as exhibited in Japanese fetal specimens housed at Kyoto University. A total of 31 human fetal specimens aged from approximately 8 to 42 weeks of gestation underwent helical computed tomographic scanning, and 68 landmarks were digitized on the internal and external surfaces of the extracted crania. Ontogenetic shape change was then analyzed cross-sectionally and three-dimensionally using a geometric morphometric technique. The results of the present study are generally consistent with previously reported findings. It was found that during the prenatal ontogenetic process, the growth rate of the length of the cranium is greater than that of the width and height, and the growth rate of the length of the posterior cranial base is smaller than that of the anterior cranial base. Furthermore, it was observed that the change in shape of the human viscerocranium is smaller than that of the neurocranium during the fetal period, and that concurrently the basicranium extends by approximately 8 degrees due to the relative elevation of the basilar and lateral parts of occipital bone. These specific growth-related changes are the opposite of those reported for the postnatal period. Our findings therefore indicate that the allometric pattern of the human cranium is not a simple continuous transformation, but changes drastically from before to after birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.