ArticleParasitology research2008
Fas/FasL-dependent apoptosis of hepatocytes induced in rat and patients with Clonorchis sinensis infection.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Serum metabolic profiling of rats infected withFrontiers in cellular and infection microbiology · 2022Article
- Long Non-Coding RNA and mRNA Expression Analysis in Liver of Mice WithFrontiers in cellular and infection microbiology · 2021Article
- Perturbations of Metabolomic Profiling of Spleen From Rats Infected WithFrontiers in molecular biosciences · 2020Article
- Molecular Identification and Phylogenetic Analysis of Nuclear rDNA Sequences ofFrontiers in microbiology · 2019Article
- Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection.BMC infectious diseases · 2017Article
- Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection.BMC infectious diseases · 2016Article
- Article
- A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China.PloS one · 2012Article
- Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory-secretory antigen-fructose-1,6-bisphosphatase.Parasitology research · 2011Article
- Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis.Parasitology research · 2011Article
- Apoptosis induced by parasitic diseases.Parasites & vectors · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the injury and pathogenesis of Clonorchis sinensis (C. sinensis) to hepatocytes, the liver samples from Wistar rats and patients with C. sinensis infection were examined. The typical histopathological findings of clonorchiasis were observed in rats 4 to 12 weeks postinfection, and majority hepatocytes exhibited hydropic degeneration, even some hepatocytes showed densely condensed nuclei suggesting apoptosis in liver tissue. Apoptosis was found around the central vein or portal areas of liver tissue in rat infected with C. sinensis by transferase uridyl nick end labeling (TUNEL) assay. Compared with normal control, TUNEL-positive cells in liver tissue increase from 4 to 12 weeks postinfection with the peak at 8 weeks. Furthermore, the expression of mRNA and protein of Fas, FasL, and caspase-3 was stronger in infected group than normal control using semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Autopsy specimens from four patients infected with C. sinensis have the same findings detected by histopathology, TUNEL, and immunohistochemistry. These findings suggest that the C. sinensis can stimulate both hepatocytic apoptosis and hydropic degeneration that may be responsible for relationship between clinical manifestations and liver lesions in patients with clonorchiasis. These data also indicate a role for Fas/FasL-mediated pathway in the apoptosis that occurs in response to C. sinensis infection.
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