ReviewPflugers Archiv : European journal of physiology2008
Cell models for studying renal physiology.
Review in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment.Stem cell reports · 2026Article
- A Novel Human Distal Tubuloid-on-a-Chip Model for Investigating Sodium and Water Transport Mechanisms.Kidney360 · 2025Article
- Review
- Review
- Mechanistic Computational Models of Epithelial Cell Transporters-the Adorned Heroes of Pharmacokinetics.Frontiers in pharmacology · 2021Review
- Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.Scientific reports · 2019Article
- Establishment of renal proximal tubule cell lines derived from the kidney of p53 knockout mice.Cytotechnology · 2019Article
- Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.The AAPS journal · 2016Review
- Epithelial monolayer culture system for real-time single-cell analyses.Physiological reports · 2014Article
- Isolation and characterization of a primary proximal tubular epithelial cell model from human kidney by CD10/CD13 double labeling.PloS one · 2013Article
- Shiga toxin pathogenesis: kidney complications and renal failure.Current topics in microbiology and immunology · 2012Review
- A rapid and simple procedure for the establishment of human normal and cancer renal primary cell cultures from surgical specimens.PloS one · 2011Article
- The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.The Journal of biological chemistry · 2011Article
- alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.Journal of the American Society of Nephrology : JASN · 2011Article
- Gd-labeled microparticles in MRI: in vivo imaging of microparticles after intraperitoneal injection.Small (Weinheim an der Bergstrasse, Germany) · 2010Article
- Article
- Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters.Cell and tissue research · 2010Article
- A molecularly guided tour along the nephron.Pflugers Archiv : European journal of physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development over the past 20 years of a variety of cultured renal tubule cell lines derived from different parts of the renal tubule has provided invaluable powerful cell systems for in vitro analyses of the various tubule segment-specific biochemical functions and ion transport processes. Immortalized cell lines have been established using different hybrid gene constructs, most of them carrying the immortalizing simian virus 40 large T antigen (Tag) gene. The development of transgenic mice carrying unregulated Tag, and of others in which the expression of Tag remains controlled, has made it possible to establish permanent cell lines derived from microdissected or immunoselected renal proximal, distal, and collecting duct tubules. This review summarizes the different strategies of cellular immortalization used and the most frequently used human, rabbit, rat, and mouse tubule cell lines. This review provides an overview of the use of immortalized mouse tubule cell lines for in vitro analyses of various tubule cell-specific functions and the regulation of ion transporters and membranous channels. The advantages of using primary cultures of isolated tubules dissected from physiopathological models of transgenic mice are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.