ArticleIntensive care medicine2008
Variability in the concentrations of intravenous drug infusions prepared in a critical care unit.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic evidence review of rates and burden of harm of intravenous admixture drug preparation errors in healthcare settings.BMJ open · 2017Pooled it
- Inhomogeneity of noradrenaline levels in syringe pump systems and how to prevent it: an in vitro study.BMC anesthesiology · 2026Article
- Factors influencing accuracy when preparing injectable drug concentrations in appliance with clinical practice: a norepinephrine case study.European journal of hospital pharmacy : science and practice · 2024Article
- Intravenous therapy device labeling in Intensive Care Units: an integrative review.Revista brasileira de enfermagem · 2022Review
- Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon.Drug delivery and translational research · 2019Article
- Robotic Therapy: Cost, Accuracy, and Times. New Challenges in the Neonatal Intensive Care Unit.Frontiers in pharmacology · 2019Article
- Accuracy of intravenous and enteral preparations involving small volumes for paediatric use: a review.European journal of hospital pharmacy : science and practice · 2018Review
- Infusion medication concentrations in UK's critical care areas: Are the Intensive Care Society's recommendations being used?Journal of the Intensive Care Society · 2017Article
- Iatrogenic magnesium toxicity following intravenous infusion of magnesium sulfate: risks and strategies for prevention.BMJ case reports · 2015Article
- Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics.Drug delivery and translational research · 2014Article
- Do centrally pre-prepared solutions achieve more reliable drug concentrations than solutions prepared on the ward?Intensive care medicine · 2011Article
- Impact of simulation-based learning on medication error rates in critically ill patients.Intensive care medicine · 2010Article
- Year in review in Intensive Care Medicine, 2008: III. Paediatrics, ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea.Intensive care medicine · 2009Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation.
designAudit carried out over 3 weeks in May 2006 and completed in May 2007.
settingThe adult neurosciences critical care unit of a UK university teaching hospital.
interventionsDaily collections of discarded syringes containing midazolam, insulin, norepinephrine, dopamine, potassium or magnesium. MEASUREMENTS AND
resultsResidual solutions in the syringes were sampled and the concentrations measured. Syringe labels were inspected and awarded a score for labeling quality based on an 11-point scale. A total of 149 syringes were analyzed. Six of the magnesium syringes contained 4-5 times too much Mg(2+), presumably because of confusion about converting millimoles to grams. The majority of the other infusions differed from the expected concentration by more than 10%. Magnesium infusions were least likely to be properly labeled (p= 0.012), and there was a positive correlation between quality of syringe labeling and drug preparation (p=0.002). After the introduction of a new electrolyte prescription chart, magnesium and potassium preparation significantly improved but there was still substantial variability.
conclusionsThese findings present a strong argument for the use of pre-prepared syringes or standardized drug preparation and labeling systems. They also highlight once again the difficulties healthcare professionals encounter when dealing with different ways of expressing drug concentrations.
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18427780What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.