ArticleTransactions of the American Ophthalmological Society2007
Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases.
Article in Transactions of the American Ophthalmological Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- Anatomical and Functional Outcomes after Endoresection and Adjuvant Ruthenium Brachytherapy for Uveal Melanoma: A Single-Center Experience.Life (Basel, Switzerland) · 2023Article
- Uveal melanoma patient attitudes towards prognostic testing using gene expression profiling.Melanoma management · 2022Article
- Novel Guarded Needle Trans-Scleral Biopsy for Uveal Melanoma: A Pilot Study.Ocular oncology and pathology · 2021Article
- Blood Biomarkers of Uveal Melanoma: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Review
- Recent advancements in the management of retinoblastoma and uveal melanoma.F1000Research · 2018Review
- Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions.Clinical ophthalmology (Auckland, N.Z.) · 2018Review
- Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics.Diagnostic pathology · 2017Article
- Tumor-height regression rate after brachytherapy between choroidal melanoma gene expression profile classes: effect of controlling for tumor height.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Clinical, optical coherence tomography, and fundus autofluorescence findings in patients with intraocular tumors.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- Clinical findings and genetic expression profiling of three pigmented lesions of the optic nerve.Case reports in ophthalmological medicine · 2015Article
- Diagnostic vitrectomy for infectious uveitis.International ophthalmology clinics · 2014Review
- Frequency, molecular pathology and potential clinical significance of partial chromosome 3 aberrations in uveal melanoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the feasibility of genetic testing of uveal melanoma using fine-needle aspiration biopsy (FNAB).
methodsNoncomparative case series of 140 patients in which FNAB was performed immediately prior to plaque radiotherapy. The specimen was sent for genetic analysis using DNA amplification and microsatellite assay for evaluation for monosomy 3.
resultsMonosomy 3 was found in 44 cases (32%) and disomy 3 in 76 cases (54%); genomic DNA yield was insufficient for genetic analysis in 20 cases (14%). Monosomy 3 was found in 26% of small melanomas (16/61), 36% of medium melanomas (24/67), and 33% of large melanomas (4/12). Adequate DNA was achieved in 97% of cases using a 27-gauge needle via transvitreal tumor apex approach and in 75% of cases using a 30-gauge needle via transscleral tumor base approach. Factors predictive of monosomy 3 included greater tumor basal dimension (P = .016) and greater distance from the optic disc (P = .019). Transient localized vitreous hemorrhage was found in 46% of eyes. There was no case of diffuse vitreous hemorrhage, retinal detachment, or tumor recurrence along the biopsy tract.
conclusionsFNAB provides adequate DNA in most cases for genetic analysis of uveal melanoma using microsatellite assay.
Indexed as
Identifiers
18427593PMC2258107W1487654146What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.