Trial reportCirculation2008
Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass grafts.
Trial report in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- Postoperative complications of coronary artery bypass grafting: a narrative review on pathophysiology, management strategies, and the emerging role of artificial intelligence.Cardiovascular diagnosis and therapy · 2026Review
- Association between the American Heart Association's New Life's Essential 8 Metrics and Depression Symptom in U.S General Adults, Finding from NHANES 2005-2018.Frontiers in psychiatry · 2024Article
- The pathophysiology and management of depression in cardiac surgery patients.Frontiers in psychiatry · 2023Review
- Perceptions of US Adolescents and Adults With Sickle Cell Disease on Their Quality of Care.JAMA network open · 2020Article
- Anxiety and health-related quality of life after cardiac surgery.Archives of medical sciences. Atherosclerotic diseases · 2020Article
- Evaluation of Depression and Anxiety in Coronary Artery Bypass Surgery Patients: A Prospective Clinical Study.Brazilian journal of cardiovascular surgery · 2019Article
- Pre-surgical depression and anxiety and recovery following coronary artery bypass graft surgery.Journal of behavioral medicine · 2017Article
- Depression in Cardiovascular Patients in Middle Eastern Populations: A Literature Review.Journal of immigrant and minority health · 2015Review
- Antioxidants, inflammation and cardiovascular disease.World journal of cardiology · 2014Review
- Use of selective serotonin reuptake inhibitors and outcomes in pulmonary arterial hypertension.Chest · 2013Article
- Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.Cardiovascular psychiatry and neurology · 2013Article
- Functional capacity is a better predictor of coronary heart disease than depression or abnormal sleep duration in Black and White Americans.Sleep medicine · 2012Article
- Study exploring depression and cardiovascular diseases amongst Arabic speaking patients living in the State of Qatar: Rationale and methodology.Global cardiology science & practice · 2012Review
- The puzzle of depression and acute coronary syndrome: reviewing the role of acute inflammation.Journal of psychosomatic research · 2011Review
- Article
- Recurrent major depression predicts progression of coronary calcification in healthy women: Study of Women's Health Across the Nation.Psychosomatic medicine · 2010Article
- Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.European heart journal · 2010Article
- The impact of depression in heart disease.Current psychiatry reports · 2010Review
- Self-reported anxiety and the risk of clinical events and atherosclerotic progression among patients with Coronary Artery Bypass Grafts (CABG).American heart journal · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDepressive symptoms have been associated with increased risk of coronary artery disease and poor prognosis among patients with existing coronary artery disease, but whether depressive symptoms specifically influence atherosclerotic progression among such patients is uncertain. METHODS AND
resultsThe Post-CABG Trial randomized patients with a history of coronary bypass graft surgery to either an aggressive or a moderate lipid-lowering strategy and to either warfarin or placebo. Coronary angiography was conducted at enrollment and after a median follow-up of 4.2 years. Depressive symptoms were assessed at enrollment with the Centers for Epidemiologic Studies Depression scale (CES-D) in 1319 patients with 2496 grafts. In models that adjusted for age, gender, race, treatment assignment, and years since coronary bypass graft surgery, a CES-D score > or =16 was positively associated with risk of substantial graft disease progression (OR 1.50, 95% CI 1.08 to 2.10, P=0.02) and marginally associated with a 0.11-mm (95% CI -0.22 to 0.01 mm, P=0.07) decrease in minimum lumen diameter, but not with risk of graft occlusion (P=0.30). Additional adjustment for past medical history, blood pressure, and renal function did not materially alter these results. This association was virtually absent among participants randomly assigned to aggressive lipid-lowering therapy.
conclusionsThese findings suggest that depressive symptoms are associated with a higher risk of atherosclerotic progression among patients with saphenous vein grafts and that aggressive lipid lowering can minimize this increased risk. Whether depressive symptoms increase progression in other types of coronary atherosclerosis and whether aggressive lipid lowering attenuates such progression will require additional study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.