ArticleProceedings of the National Academy of Sciences of the United States of America2008
Protein exchange dynamics at chemoreceptor clusters in Escherichia coli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Spontaneous switching in a protein signalling array reveals near-critical cooperativity.Nature physics · 2026Article
- Protein-protein interfaces in chemotaxis receptor complexes and their role in signaling.FEMS microbiology reviews · 2026Review
- Single-array measurements reveal non-uniform, mosaic-like chemosensory arrays in bacteria.Nature communications · 2025Article
- Integrating natural language processing and genome analysis enables accurate bacterial phenotype prediction.NAR genomics and bioinformatics · 2025Article
- Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli.The EMBO journal · 2025Article
- CheB localizes to polar receptor arrays during repellent adaptation.Science advances · 2024Article
- Alternative Architecture of theBiomolecules · 2021Article
- A hidden state in the turnover of a functioning membrane protein complex.Science advances · 2019Article
- Article
- Optogenetic Manipulation of Cyclic Di-GMP (c-di-GMP) Levels Reveals the Role of c-di-GMP in Regulating Aerotaxis Receptor Activity in Azospirillum brasilense.Journal of bacteriology · 2017Article
- The effect of antibiotics on protein diffusion in the Escherichia coli cytoplasmic membrane.PloS one · 2017Article
- Single-molecule imaging of electroporated dye-labelled CheY in live Escherichia coli.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Caulobacter PopZ forms an intrinsically disordered hub in organizing bacterial cell poles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- C4-Dicarboxylate Utilization in Aerobic and Anaerobic Growth.EcoSal Plus · 2016Article
- Bacterial protein networks: properties and functions.Nature reviews. Microbiology · 2015Review
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- Article
- Single- and two-photon fluorescence recovery after photobleaching.Cold Spring Harbor protocols · 2015Article
- Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges.Current opinion in structural biology · 2014Review
- Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Signal processing in bacterial chemotaxis relies on large sensory complexes consisting of thousands of protein molecules. These clusters create a scaffold that increases the efficiency of pathway reactions and amplifies and integrates chemotactic signals. The cluster core in Escherichia coli comprises a ternary complex composed of receptors, kinase CheA, and adaptor protein CheW. All other chemotaxis proteins localize to clusters by binding either directly to receptors or to CheA. Here, we used fluorescence recovery after photobleaching (FRAP) to investigate the turnover of chemotaxis proteins at the cluster and their mobility in the cytoplasm. We found that cluster exchange kinetics were protein-specific and took place on several characteristic time scales that correspond to excitation, adaptation, and cell division, respectively. We further applied analytical and numerical data fitting to analyze intracellular protein diffusion and to estimate the rate constants of cluster equilibration in vivo. Our results indicate that the rates of protein turnover at the cluster have evolved to ensure optimal performance of the chemotaxis pathway.
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