ArticleProceedings of the National Academy of Sciences of the United States of America2008
The mitotic kinesin CENP-E is a processive transport motor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Mechanical states of a motor protein in the spindle.Current biology : CB · 2026Article
- Kinesin-7 CENP-E mediates centrosome organization and spindle assembly to regulate chromosome alignment and genome stability.Cell proliferation · 2025Article
- Analyzing the expression and clinical significance of CENPE in gastric cancer.BMC medical genomics · 2024Article
- Reconstitution of an active human CENP-E motor.Open biology · 2022Article
- Influence of the Season and Region Factor on Phosphoproteome of Stallion Epididymal Sperm.Animals : an open access journal from MDPI · 2021Article
- Inhibiting microcephaly genes as alternative to microtubule targeting agents to treat brain tumors.Cell death & disease · 2021Review
- Kinesin-7 CENP-E regulates the formation and structural maintenance of the acrosome.Cell and tissue research · 2021Article
- RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation.Frontiers in molecular biosciences · 2021Article
- Leaving no-one behind: how CENP-E facilitates chromosome alignment.Essays in biochemistry · 2020Review
- Force production of human cytoplasmic dynein is limited by its processivity.Science advances · 2020Article
- Kinesin-7 CENP-E regulates chromosome alignment and genome stability of spermatogenic cells.Cell death discovery · 2020Article
- Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1.Scientific reports · 2019Article
- Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity.Nature communications · 2019Article
- Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers.Biophysical journal · 2018Article
- In vitro reconstitution of lateral to end-on conversion of kinetochore-microtubule attachments.Methods in cell biology · 2018Article
- Chromosome biorientation produces hundreds of piconewtons at a metazoan kinetochore.Nature communications · 2016Article
- Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.Biophysical reviews · 2015Article
- Mitosis. Microtubule detyrosination guides chromosomes during mitosis.Science (New York, N.Y.) · 2015Article
- Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy.Bioconjugate chemistry · 2014Article
- Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function.Biophysical journal · 2014Article
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5 authors.
Funding
Abstract
In vivo studies suggest that centromeric protein E (CENP-E), a kinesin-7 family member, plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. How CENP-E accomplishes this crucial task, however, is not clear. Here we present single-molecule measurements of CENP-E that demonstrate that this motor moves processively toward the plus end of microtubules, with an average run length of 2.6 +/- 0.2 mum, in a hand-over-hand fashion, taking 8-nm steps with a stall force of 6 +/- 0.1 pN. The ATP dependence of motor velocity obeys Michaelis-Menten kinetics with K(M,ATP) = 35 +/- 5 muM. All of these features are remarkably similar to those for kinesin-1-a highly processive transport motor. We, therefore, propose that CENP-E transports chromosomes in a manner analogous to how kinesin-1 transports cytoplasmic vesicles.
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