Trial reportHypertension (Dallas, Tex. : 1979)2008
Forearm vascular reactivity and arterial stiffness in asymptomatic adults from the community.
Trial report in Hypertension (Dallas, Tex. : 1979), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.American journal of physiology. Heart and circulatory physiology · 2011 · on this mapGuideline
- Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.Hemodialysis international. International Symposium on Home Hemodialysis · 2011Trial
- Muscle microvascular reactivity and its associations with arterial stiffness and aortic pressures in postmenopausal women with abdominal obesity and hypertension.Journal of human hypertension · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Hypertensive women with dyspnea exhibit an unfavorable central blood pressure response to exercise.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis.BMC cardiovascular disorders · 2025Article
- Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study.BMJ open · 2024Article
- High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study.Biology of sex differences · 2022Article
- Article
- Individual and combined contributions of age-specific and sex-specific pulse pressure and brachial-ankle pulse wave velocity to the risk of new-onset diabetes mellitus.BMJ open diabetes research & care · 2021Article
- Age-associated impairments in contraction-induced rapid-onset vasodilatation within the forearm are independent of mechanical factors.Experimental physiology · 2018Article
- Carotid artery reactivity during sympathetic activation following acute resistance exercise.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Cardiovascular risk assessment in patients with rheumatoid arthritis: a correlative study of noninvasive arterial health testing.Clinical rheumatology · 2017Article
- Endothelial dysfunction state in migraine headache and neutrally mediated syncope in children and young adults.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Associations between arterial stiffness and platelet activation in normotensive overweight and obese young adults.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2014Article
- Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case-control study.The journal of headache and pain · 2013Article
- Relation between digital peripheral arterial tonometry and brachial artery ultrasound measures of vascular function in patients with coronary artery disease and in healthy volunteers.The American journal of cardiology · 2012Article
- The association of arterial shear and flow-mediated dilation in diabetes.Vascular medicine (London, England) · 2011Article
- Race, psychosocial factors, and aortic pulse wave velocity: the Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vascular reactivity may affect the stiffness characteristics of the arterial wall. We investigated the association between forearm microcirculatory and conduit artery function and measures of arterial stiffness in 527 asymptomatic non-Hispanic white adults without known cardiovascular disease. High-resolution ultrasonography of the brachial artery (ba) was performed to assess forearm microcirculatory function (ba blood flow velocity, local shear stress, and forearm vascular resistance at rest and during reactive hyperemia) and conduit artery function (ba flow-mediated dilatation [baFMD] and ba nitroglycerin-mediated dilatation [baNMD]). Arterial stiffness was assessed by cuff-derived brachial pulse pressure and aortic pulse wave velocity (aPWV) measured by applanation tonometry. In regression analyses that adjusted for heart rate, mean arterial pressure, height, cardiovascular risk factors, and hypertension medication and statin use, higher baseline ba systolic velocity and systolic shear stress were associated with greater pulse pressure (P=0.0002 and P=0.006, respectively) and higher aPWV (each P<0.0001). During hyperemia, lower ba mean velocity and lower mean shear stress were associated with higher pulse pressure (P=0.045 and P=0.036, respectively), whereas both systolic and mean velocity (P<0.0001 and P=0.002, respectively) and systolic and mean shear stress (P<0.0001 and P=0.003, respectively) were inversely associated with aPWV. baFMD was not associated with pulse pressure but was inversely associated with aPWV (P=0.011). baNMD was inversely associated with pulse pressure (P=0.0002) and aPWV (P=0.008). Our findings demonstrate that impaired forearm microvascular function (in the form of elevated resting blood flow velocity and impaired flow reserve) and impaired brachial artery reactivity are associated with increased arterial stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.