ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2008
The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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51 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
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- A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin.PloS one · 2012Trial
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- The association of nutritional and inflammatory status with cardiovascular and all-cause mortality risk among US patients with metabolic syndrome.Scientific reports · 2025Article
- Association of Adipokines and CIMT in Metabolic Syndrome in Western Uttar Pradesh Population: a Cross-Sectional Study.Maedica · 2024Article
- Obesity and Depression: Common Link and Possible Targets.CNS & neurological disorders drug targets · 2024Review
- Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2023Article
- Impact of Two Types of Exercise Interventions on Leptin and Omentin Concentrations and Indicators of Lipid and Carbohydrate Metabolism in Males with Metabolic Syndrome.Journal of clinical medicine · 2023Article
- Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies.Frontiers in nutrition · 2023Review
- Sex-specific prevalence of metabolic syndrome in older adults: results from the Neyshabur longitudinal study on aging, Iran.Journal of diabetes and metabolic disorders · 2022Article
- Exercise training modulates adipokine dysregulations in metabolic syndrome.Sports medicine and health science · 2022Review
- Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome.Journal of diabetes and metabolic disorders · 2021Article
- Exposure to High-Fat Style Diet Induced Renal and Liver Structural Changes, Lipid Accumulation and Inflammation in Intact and Ovariectomized Female Rats.Journal of inflammation research · 2021Article
- The untwining of immunosenescence and aging.Seminars in immunopathology · 2020Review
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- The influence of theAging · 2018Article
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- Osteoarthritis of knee joint in metabolic syndrome.Clinical rheumatology · 2018Article
- Association of Markers of Proinflammatory Phenotype and Beige Adipogenesis with Metabolic Syndrome in Chinese Centrally Obese Adults.Journal of diabetes research · 2018Article
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9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCirculating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults.
methodsA cross-sectional analysis was conducted including 1914 individuals aged 70-79 years without cardiovascular disease or type 2 diabetes. The metabolic syndrome was defined by the updated Adult Treatment Panel III criteria. Circulating levels of leptin, adiponectin, plasminogen activator inhibitor type 1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured. Body composition and abdominal visceral fat area were determined.
resultsBoth the presence of metabolic syndrome and the number of metabolic syndrome components were associated with higher levels of leptin, PAI-1, IL-6, TNF-alpha, and CRP and with lower levels of adiponectin (all p <.0001). The odds ratios for the prevalence of metabolic syndrome associated with adipokines were attenuated after adjustment for total fat mass and/or visceral fat area, but remained significant. Levels of leptin, PAI-1, IL-6, and TNF-alpha were higher (all p <.05 to p <.0001), and adiponectin was lower (all p <.0001), in persons with, compared to those without, metabolic syndrome within each tertile of percent body fat.
conclusionThe metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity, including in those with low or normal overall fatness.
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