ArticleInfection and immunity2008
Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 82 citations in OpenAlex.
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- Associations betweenJournal of fungi (Basel, Switzerland) · 2021Review
- The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks.Fungal diversity · 2021Review
- An intergenic "safe haven" region in Cryptococcus neoformans serotype D genomes.Fungal genetics and biology : FG & B · 2020Article
- Virulence phenotypes result from interactions between pathogen ploidy and genetic background.Ecology and evolution · 2020Article
- Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.Microorganisms · 2020Review
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- The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis ofAnnual review of genetics · 2019Review
- Silkworm as an experimental animal for research on fungal infections.Microbiology and immunology · 2019Review
- Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.Molecular microbiology · 2018Article
- Plant Homeodomain Genes Play Important Roles in Cryptococcal Yeast-Hypha Transition.Applied and environmental microbiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hybridization with polyploidization is a significant biological force driving evolution. The effect of combining two distinct genomes in one organism on the virulence potential of pathogenic fungi is not clear. Cryptococcus neoformans, the most common cause of fungal infection of the central nervous system, has a bipolar mating system with a and alpha mating types and occurs as A (haploid), D (haploid), and AD hybrid (mostly diploid) serotypes. Diploid AD hybrids are derived either from a-alpha mating or from unisexual mating between haploid cells. The precise contributions of increased ploidy, the effect of hybridization between serotypes A and D, and the combination of mating types to the virulence potential of AD hybrids have remained elusive. By using in vitro and in vivo characterization of laboratory-constructed isogenic diploids and AD hybrids with all possible mating type combinations in defined genetic backgrounds, we found that higher ploidy has a minor negative effect on virulence in a murine inhalation model of cryptococcosis. The presence of both mating types a and alpha in AD hybrids did not affect the virulence potential, irrespective of the serotype origin. Interestingly, AD hybrids with only one mating type behaved differently, with the virulence of alphaADalpha strains similar to that of other hybrids, while aADa hybrids displayed significantly lower virulence due to negative epistatic interactions between the Aa and Da alleles of the mating type locus. This study provides insights into the impact of ploidy, mating type, and serotype on virulence and the impact of hybridization on the fitness and virulence of a eukaryotic microbial pathogen.
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