ArticleDiabetes2008
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.Clinical endocrinology · 2014Pooled it
- Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Diabetologia · 2012Pooled it
- Pooled it
- Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?PLoS genetics · 2009Pooled it
- Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.Diabetologia · 2008Trial
- The mActa pharmacologica Sinica · 2022Article
- Genomics of body fat distribution.Journal of genetics · 2021Review
- Obesity and Heath-Carter Somatotyping of 3438 Adults in the Xinjiang Uygur Autonomous Region of China by Multivariate Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Ancestry specific associations of FTO gene variant and metabolic syndrome: A longitudinal ARIC study.Medicine · 2020Observational
- Association of FTO common variant (rs9939609) with body fat in Turkish individuals.Lipids in health and disease · 2019Article
- Association of a common rs9939609 variant in the fat mass and obesity-associated (FTO) gene with obesity and metabolic phenotypes in a Taiwanese population: a replication study.Journal of genetics · 2016Article
- The Elevated Susceptibility to Diabetes in India: An Evolutionary Perspective.Frontiers in public health · 2016Review
- Suppressor of cytokine signaling 3 A+930-->G (rs4969168) polymorphism is associated with apolipoprotein A1 and low-density lipoprotein cholesterol.International journal of clinical and experimental pathology · 2015Article
- Care delivery for Filipino Americans using the Neuman systems model.Nursing science quarterly · 2014Article
- INSIG2 variants, dietary patterns and metabolic risk in Samoa.European journal of clinical nutrition · 2013Article
- The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults.Indian journal of endocrinology and metabolism · 2012Article
- SNP variation in ADRB3 gene reflects the breed difference of sheep populations.Molecular biology reports · 2012Article
- Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk.Nutrition research and practice · 2012Article
- The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents.International journal of obesity (2005) · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe underlying genetic component of obesity-related traits is not well understood, and there is limited evidence to support genetic association shared across multiple studies, populations, and environmental contexts. The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort. RESEARCH DESIGN AND
methodsWe selected and genotyped 19 single nucleotide polymorphisms in 10 genes (ADRB2, ADRB3, FTO, GNB3, INSIG2, LEPR, PPARG, TNF, UCP2, and UCP3) that had been previously reported to be associated with an obesity-related quantitative trait.
resultsWe observed evidence for association of the A allele of rs9939609 (FTO intron 1) with increased BMI (P = 0.0072 before multiple test correction), baseline BMI (P = 0.0015), longitudinal BMI based on eight surveys from 1983 to 2005 (P = 0.000029), waist circumference (P = 0.0094), and weight (P = 0.021). The increase in average BMI was approximately 0.4 for each additional A allele. We also observed association of the ADRB3 Trp64Arg variant with BMI, waist circumference, percent body fat, weight, fat mass, arm fat area, and arm muscle area (P < 0.05), although the direction of effect is inconsistent with the majority of previous reports.
conclusionsOur study confirms that FTO is a common obesity susceptibility gene in Filipinos, with an effect size similar to that seen in samples of European origin.
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