ReviewJournal of the Royal Society, Interface2008
Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.
Review in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Maximum Entropy Production Principle of Thermodynamics for the Birth and Evolution of Life.Entropy (Basel, Switzerland) · 2025Review
- Structure-Function Relationship Study of a Secretory Amoebic Phosphatase: A Computational-Experimental Approach.International journal of molecular sciences · 2021Article
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Protease activated-receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV.Journal of leukocyte biology · 2018Article
- Absence of catalytic domain in a putative protein kinase C (PkcA) suppresses tip dominance in Dictyostelium discoideum.Developmental biology · 2015Article
- Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation.Development, growth & differentiation · 2015Article
- Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase.Cell proliferation · 2015Article
- Cell polarity: netrin calms an excitable system.Current biology : CB · 2014Article
- Cell signaling during development of Dictyostelium.Developmental biology · 2014Review
- Article
- Regulation of aggregate size and pattern by adenosine and caffeine in cellular slime molds.BMC developmental biology · 2012Article
- Cell density sensing and size determination.Development, growth & differentiation · 2011Review
- A cAMP signaling model explains the benefit of maintaining two forms of phosphodiesterase in Dictyostelium.Biophysical journal · 2009Article
- A cell number counting factor alters cell metabolism.Communicative & integrative biology · 2009Article
- Biological switches and clocks.Journal of the Royal Society, Interface · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Little is known about how the sizes of specific organs and tissues are regulated. To try to understand these mechanisms, we have been using a combination of modelling and experiments to study the simple system Dictyostelium discoideum, which forms approximately 20000 cell groups. We found that cells secrete a factor, and as the number of cells increases, the concentration of the factor increases. Diffusion calculations indicated that this lets cells sense the local cell density. Computer simulations predicted, and experiments then showed, that this factor decreases cell-cell adhesion and increases random cell motility. In a group, adhesion forces keep cells together, while random motility forces cause cells to pull apart and separate from each other. As the group size increases above a threshold, the factor concentration goes above a threshold and the cells switch from an adhered state to a separated state. This causes excessively large groups to break apart and/or dissipate, creating an upper limit to group size. In this review, we focus on how computer simulations made testable predictions that led the way to understanding the size regulation mechanism mediated by this factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.