Evidence map›Paper›PMID 18425939›Full record

SynthesisThe Cochrane database of systematic reviews2008

Exercise for the management of cancer-related fatigue in adults.

F Cramp, J Daniel

6 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 144 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01228773 phase2unknown statusnot on this mapstarted 2009, after this paper: background citation

The Efficacy of Web-based, Tailored Program(Health Navigation®) for the Management of Cancer-Related Fatigue in Cancer Survivors

TypeinterventionalSponsorNational Cancer Center, KoreaRan2009 to 2010Enrolled266ConditionsCancer-related FatigueArmsTailored web-based care program (Health Navigation®)
NCT01711580 withdrawnnot on this mapstarted 2013, after this paper: background citation

Re-irradiation of High Grade Gliomas: a Quality of Life Study

TypeobservationalSponsorMaastricht Radiation OncologyRan2013 to 2015Enrolled0ConditionsAnaplastic Astrocytoma, Glioblastoma Multiforme, Anaplastic OligoastrocytomaArmsEORTC QLQ-C30, EORTC QLQ-BN20, Hopkins Verbal Learning Test-Revised (HVLT-R), Stroop color-word test, Controlled oral word association test (COWA)
NCT01954706 naterminatednot on this mapstarted 2013, after this paper: background citation

Pilot Trial of Aerobic and Resistance Exercise Training for the Primary Prevention of Musculoskeletal Side Effects From Aromatase Inhibitors in Postmenopausal Breast Cancer Patients

TypeinterventionalSponsorBaltimore VA Medical CenterRan2013 to 2015Enrolled5ConditionsBreast Cancer, SarcopeniaArmsStructured Exercise, Usual Care
NCT03394495 nacompletednot on this mapstarted 2018, after this paper: background citation

Evaluation of an Individualized Exercise Programme Plus Behavioural Change Enhancement Strategies for Managing General Fatigue in Community-dwelling Frail Older People: A Cluster-randomized Controlled Trial.

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2018 to 2021Enrolled184ConditionsFatigueArmsBCE Combination group
NCT05009849 naactive not recruitingnot on this mapstarted 2010, after this paper: background citation

Randomized Controlled Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer

TypeinterventionalSponsorTata Memorial CentreRan2010 to 2030Enrolled850ConditionsBreast Cancer PatientsArmsYoga Exercises
NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 24 syntheses or guidelines pooled it, 384 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Cancer-Related Fatigue, Version 2.2015.Journal of the National Comprehensive Cancer Network : JNCCN · 2015
    Guideline
  6. Pooled it
  7. Effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  8. Guideline
  9. Cancer-related fatigue in the elderly.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Pooled it
  10. Pooled it
  11. Exercise for the management of cancer-related fatigue in adults.The Cochrane database of systematic reviews · 2012
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Blood transfusions for anaemia in patients with advanced cancer.The Cochrane database of systematic reviews · 2012
    Pooled it
  15. Pooled it
  16. Pooled it
  17. Exercise interventions for cancer survivors: a meta-analysis of quality of life outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2011
    Pooled it
  18. The effects of resistance training on quality of life in cancer: a systematic literature review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010
    Pooled it
  19. Pooled it
  20. Drug therapy for the management of cancer-related fatigue.The Cochrane database of systematic reviews · 2010
    Pooled it

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

F CrampUniversity of the West of England, School of Allied Health Professions, Glenside Campus, Blackberry Hill, Bristol, UK, BS16 1DD. fiona.cramp@uwe.ac.uk
J Daniel
University of the West of England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer-related fatigue is now recognised as an important symptom associated with cancer and its treatment. A number of studies have investigated the effects of physical activity in reducing cancer-related fatigue with no definitive conclusions regarding its effectiveness.

objectivesTo evaluate the effect of exercise on cancer-related fatigue both during and after cancer treatment. SEARCH STRATEGY: The Cochrane Controlled Trials Register (CENTRAL/CCTR), MEDLINE (1966 to July 2007), EMBASE (1980 to July 2007), CINAHL (1982 to July 2007), British Nursing Index (January 1984 to July 2007), AMED (1985 to July 2007), SIGLE (1980 to July 2007), and Dissertation Abstracts International (1861 to July 2007) were all searched using key words. Reference lists off all studies identified for inclusion and relevant reviews were also searched. In addition, relevant journals were hand searched and experts in the field of cancer-related fatigue were contacted. SELECTION CRITERIA: Randomised controlled trials (RCTs) that investigated the effect of exercise on cancer-related fatigue in adults were included. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed the methodological quality of studies and extracted data based upon predefined criteria. Where data were available meta-analyses were performed for fatigue using a random-effects model. MAIN

resultsTwenty-eight studies were identified for inclusion (n = 2083 participants), with the majority carried out on participants with breast cancer (n = 16 studies; n = 1172 participants). A meta-analysis of all fatigue data, incorporating 22 comparisons provided data for 920 participants who received an exercise intervention and 742 control participants. At the end of the intervention period exercise was statistically more effective than the control intervention (SMD -0.23, 95% Confidence Interval (CIs) -0.33 to -0.13). AUTHORS'

conclusionsExercise can be regarded as beneficial for individuals with cancer-related fatigue during and post cancer therapy. Further research is required to determine the optimal type, intensity and timing of an exercise intervention.

Indexed as

ExerciseAdultFatigueHumansNeoplasmsRandomized Controlled Trials as Topic

Identifiers

PMID18425939
OpenAlexW1037238025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.