ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Placental molecular subtypes of severe preeclampsia reveal divergent aging trajectories and fetal growth outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.Cell death & disease · 2020Article
- The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach.Scientific reports · 2019Article
- Genome-wide genotyping uncovers genetic diversity, phylogeny, signatures of selection, and population structure of Chinese Jiangquhai pigs in a global perspective1.Journal of animal science · 2019Article
- Heterozygous LHX3 mutations may lead to a mild phenotype of combined pituitary hormone deficiency.European journal of human genetics : EJHG · 2019Article
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
The LIM homeobox containing genes of the LIM-3 group, Lhx3 and Lhx4, are critical for normal development. Both genes are involved in the formation of the pituitary and the motoneuron system and loss of either gene causes perinatal lethality. Previous studies had shown that Lhx3 is overexpressed in hyperplastic placentas of mouse interspecies hybrids. To determine the role of LHX3 in the mouse placenta, we performed expression and function analyses. Our results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta. However, deletion of Lhx3 does not produce a placental phenotype. To test whether this is due to functional substitution by Lhx4, we performed a phenotype analysis of Lhx3-/-; Lhx4-/- double-mutant placentas. A subset of Lhx3-/-; Lhx4-/- placentas exhibited abnormal structure of the labyrinth. However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr. Thus, LHX3 and LHX4 appear to be dispensable for placental development and function.
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