ArticleJournal of cellular physiology2008
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.
Article in Journal of cellular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling.Cell reports · 2024Article
- Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal.International journal of molecular sciences · 2021Review
- Netrin-1 promotes epithelium repair in corneal injury.International journal of ophthalmology · 2020Article
- Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration.Biochemical and biophysical research communications · 2019Article
- Differential expression of neurogenes among breast cancer subtypes identifies high risk patients.Oncotarget · 2016Article
- Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.The American journal of pathology · 2015Article
- A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.Breast cancer research : BCR · 2015Article
- Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia.Neuroscience bulletin · 2014Review
- Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.The American journal of pathology · 2012Review
- Cell-matrix interactions in mammary gland development and breast cancer.Cold Spring Harbor perspectives in biology · 2010Review
- Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells.Stem cells (Dayton, Ohio) · 2010Article
- CrkII transgene induces atypical mammary gland development and tumorigenesis.The American journal of pathology · 2010Article
- Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells.Cancer research · 2009Article
- Functional Roles of Netrin-1 in Osteoblast Differentiation.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Netrin-1 has been shown to regulate the function of the EGF-like protein Cripto-1 (Cr-1) and affect mammary gland development. Since Cr-1 is a target gene of Nanog and Oct4, we investigated the relationship between Netrin-1 and Cr-1, Nanog and Oct4 during different stages of development in the mouse mammary gland. Results from histological analysis show that exogenous Netrin-1 was able to induce formation of alveolar-like structures within the mammary gland terminal end buds of virgin transgenic Cripto-1 mice and enhance mammary gland alveologenesis in early pregnant FVB/N mice. Results from immunostaining and Western blot analysis show that Netrin-1, Nanog and Oct4 are expressed in the mouse embryonic mammary anlage epithelium while Cripto-1 is predominantly expressed outside this structure in the surrounding mesenchyme. We find that in lactating mammary glands of postnatal FVB/N mice, Netrin-1 expression is highest while Cripto-1 and Nanog levels are lowest indicating that Netrin-1 may perform a role in the mammary gland during lactation. HC-11 mouse mammary epithelial cells stimulated with lactogenic hormones and exogenous soluble Netrin-1 showed increased beta-casein expression as compared to control thus supporting the potential role for Netrin-1 during functional differentiation of mouse mammary epithelial cells. Finally, mouse ES cells treated with exogenous soluble Netrin-1 showed reduced levels of Nanog and Cripto-1 and higher levels of beta-III tubulin during differentiation. These results suggest that Netrin-1 may facilitate functional differentiation of mammary epithelial cells and possibly affect the expression of Nanog and/or Cripto-1 in multipotent cells that may reside in the mammary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.