ArticleJournal of molecular medicine (Berlin, Germany)2008
Increased susceptibility to endotoxic shock in transgenic rats with endothelial overexpression of kinin B(1) receptors.
Article in Journal of molecular medicine (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Kinin BPharmaceuticals (Basel, Switzerland) · 2025Article
- Kinin BInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Role of Endothelial Kinin B1 Receptor on the Membrane Potential of Transgenic Rat Aorta.Physiological research · 2022Article
- Kinins and Their Receptors in Infectious Diseases.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis.Intensive care medicine experimental · 2019Article
- Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy.Frontiers in medicine · 2018Article
- Vascular endothelial dysfunction and pharmacological treatment.World journal of cardiology · 2015Review
- A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.European journal of inflammation · 2015Article
- Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.The Journal of biological chemistry · 2013Article
- PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis.Cardiovascular & hematological agents in medicinal chemistry · 2012Article
- Cross-talk between the complement and the kinin system in vascular permeability.Immunology letters · 2011Review
- Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.The Journal of biological chemistry · 2011Article
- A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.Journal of cellular and molecular medicine · 2011Article
- Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.Neuropeptides · 2010Review
- Contact system activation in severe infectious diseases.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Predisposition to atherosclerosis and aortic aneurysms in mice deficient in kinin B1 receptor and apolipoprotein E.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Shocking effects of endothelial bradykinin B1 receptors.Journal of molecular medicine (Berlin, Germany) · 2008Article
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8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two kinin receptors have been described, the inducible B(1) and the constitutive B(2). B(1) receptors are important in cardiovascular homeostasis and inflammation. To further clarify their vascular function, we have generated transgenic rats (TGR(Tie2B(1))) overexpressing the B(1) receptor exclusively in the endothelium. Endothelial cell-specific expression was confirmed by B(1)-agonist-induced relaxation of isolated aorta, which was abolished by endothelial denudation of the vessel. This vasodilatation was mediated by nitric oxide (NO) and K(+) channels. TGR(Tie2B(1)) rats were normotensive but, in contrast to controls, reacted with a marked fall in blood pressure and increased vascular permeability after intravenous injection of a B(1) agonist. After lipopolysaccharide treatment, they present a more pronounced hypotensive response and marked bradycardia associated with increased mortality when compared to non-transgenic control animals. Thus, the transgenic rats overexpressing kinin B(1) receptors exclusively in the endothelium generated in this study support an important role of this receptor in the vasculature during the pathogenesis of endotoxic shock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.