ArticleAmerican journal of physiology. Lung cellular and molecular physiology2008
Proteasome inhibition improves diaphragm function in congestive heart failure rats.
Article in American journal of physiology. Lung cellular and molecular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction.Free radical biology & medicine · 2023Article
- Effect of optimized new Shengmai powder on exercise tolerance in rats with heart failure by regulating the ubiquitin-proteasome signaling pathway.Frontiers in cardiovascular medicine · 2023Article
- Article
- Emerging Strategies Targeting Catabolic Muscle Stress Relief.International journal of molecular sciences · 2020Review
- Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- [Diaphragm dysfunction : Facts for clinicians].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Review
- Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology.Heart failure reviews · 2017Review
- Strategies to optimize respiratory muscle function in ICU patients.Critical care (London, England) · 2016Review
- Pharmacological targeting of mitochondrial reactive oxygen species counteracts diaphragm weakness in chronic heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation.Frontiers in physiology · 2016Article
- Article
- Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm.Journal of cachexia, sarcopenia and muscle · 2015Article
- Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Self-rated health is associated with the length of stay at the intensive care unit and hospital following cardiac surgery.BMC cardiovascular disorders · 2014Article
- Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction.Critical care (London, England) · 2014Article
- Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions.PloS one · 2014Article
- Relation of respiratory muscle strength, cachexia and survival in severe chronic heart failure.Journal of cachexia, sarcopenia and muscle · 2013Article
- The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2).Biochemical pharmacology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In congestive heart failure (CHF), diaphragm weakness is known to occur and is associated with myosin loss and activation of the ubiquitin-proteasome pathway. The effect of modulating proteasome activity on myosin loss and diaphragm function is unknown. The present study investigated the effect of in vivo proteasome inhibition on myosin loss and diaphragm function in CHF rats. Coronary artery ligation was used as an animal model for CHF. Sham-operated rats served as controls. Animals were treated with the proteasome inhibitor bortezomib (intravenously) or received saline (0.9%) injections. Force generating capacity, cross-bridge cycling kinetics, and myosin content were measured in diaphragm single fibers. Proteasome activity, caspase-3 activity, and MuRF-1 and MAFbx mRNA levels were determined in diaphragm homogenates. Proteasome activities in the diaphragm were significantly reduced by bortezomib. Bortezomib treatment significantly improved diaphragm single fiber force generating capacity (approximately 30-40%) and cross-bridge cycling kinetics (approximately 20%) in CHF. Myosin content was approximately 30% higher in diaphragm fibers from bortezomib-treated CHF rats than saline. Caspase-3 activity was decreased in diaphragm homogenates from bortezomib-treated rats. CHF increased MuRF-1 and MAFbx mRNA expression in the diaphragm, and bortezomib treatment diminished this rise. The present study demonstrates that treatment with a clinically used proteasome inhibitor improves diaphragm function by restoring myosin content in CHF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.