ArticleApplied and environmental microbiology2008
Competing isogenic Campylobacter strains exhibit variable population structures in vivo.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds.eLife · 2025Article
- A sequencing-based method for quantifying gene-deletion mutants of bacteria in the intracellular environment.Frontiers in microbiology · 2024Article
- Survival Time ofThe journal of poultry science · 2024Article
- Campylobacter jejuni: targeting host cells, adhesion, invasion, and survival.Applied microbiology and biotechnology · 2023Review
- Host-Associated Rhizobial Fitness: Dependence on Nitrogen, Density, Community Complexity, and Legume Genotype.Applied and environmental microbiology · 2022Article
- Mechanisms of biodiversity betweenEcology and evolution · 2022Article
- Observations supporting hypothetical commensalism and competition between twoFrontiers in microbiology · 2022Article
- Article
- Campylobacter jejuni and Campylobacter coli autotransporter genes exhibit lineage-associated distribution and decay.BMC genomics · 2020Article
- Review on Stress Tolerance inFrontiers in cellular and infection microbiology · 2020Review
- Typing ofVeterinary and animal science · 2018Article
- Random sorting of Campylobacter jejuni phase variants due to a narrow bottleneck during colonization of broiler chickens.Microbiology (Reading, England) · 2018Article
- Influence of lauric acid on the susceptibility of chickens to an experimental Campylobacter jejuni colonisation.PloS one · 2018Article
- Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models.Scientific reports · 2017Article
- Analysis of Campylobacter jejuni infection in the gnotobiotic piglet and genome-wide identification of bacterial factors required for infection.Scientific reports · 2017Article
- Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine.PLoS biology · 2017Article
- A quantitative proteomic screen of the Campylobacter jejuni flagellar-dependent secretome.Journal of proteomics · 2017Article
- Genetic Diversity of Campylobacter jejuni and Campylobacter coli Isolates from Conventional Broiler Flocks and the Impacts of Sampling Strategy and Laboratory Method.Applied and environmental microbiology · 2016Article
- Motility defects in Campylobacter jejuni defined gene deletion mutants caused by second-site mutations.Microbiology (Reading, England) · 2015Article
- The role of probiotics in the inhibition of Campylobacter jejuni colonization and virulence attenuation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Consumption of poultry contaminated with Campylobacter jejuni is a risk factor for human gastrointestinal disease. The rational development of control strategies for Campylobacter within chickens requires an understanding of the colonization process at the molecular and population levels, both within and between hosts. Experiments employing competing strains of Campylobacter have been used to investigate colonization. Implicit in these studies is the assumption that the behavior of competing strains is reproducible between experiments. Variability in the recovery of mutants from the chicken gastrointestinal tract during signature-tagged mutagenesis studies demonstrated that this is not always the case. To further investigate this phenomenon in the absence of confounding factors due to phenotypic differences between mutants, we constructed individually identifiable wild-type isogenic tagged strains (WITS) that have indistinguishable phenotypes in pure culture. By using mixtures of WITS, it is possible to monitor the relative amounts of subpopulations of essentially wild-type bacteria. Using a 2-week-old chicken model of colonization, we observed unpredictable variations in population structure both within and between experiments, even in the simplest case of two competing strains. This variation occurred both when birds were simultaneously infected with two WITS and when birds inoculated with different WITS were cohoused. We present evidence for founder effects during initial colonization with subsequent bird-to-bird transmission. We suggest that these and phenotypic variation contribute to the observed variability. These factors render simple models of colonization which do not take them into account inappropriate for Campylobacter and impact the planning and interpretation of competition experiments using this organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.