ArticleNeuroscience2008
Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 53 citations in OpenAlex.
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- Clinical features of autonomic dysfunction in children with anti-N-methyl-D aspartic receptor encephalitis.Italian journal of pediatrics · 2025Article
- Metabolic control of ovarian function through the sympathetic nervous system: role of leptin.Frontiers in endocrinology · 2024Review
- Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia-induced peripheral chemoreflex responses.The Journal of physiology · 2023Article
- The Paraventricular Nucleus of the Hypothalamus in Control of Blood Pressure and Blood Pressure Variability.Frontiers in physiology · 2022Review
- Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways.The Journal of physiology · 2021Article
- Naringin and Trimetazidine Improve Baroreflex Sensitivity and Nucleus Tractus Solitarius Electrical Activity in Renal Ischemia-Reperfusion Injury.Arquivos brasileiros de cardiologia · 2021Article
- The PVN enhances cardiorespiratory responses to acute hypoxia via input to the nTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- The negative effects of social bond disruption are partially ameliorated by sertraline administration in prairie voles.Autonomic neuroscience : basic & clinical · 2019Article
- A Nitric Oxide-Dependent Presynaptic LTP at Glutamatergic Synapses of the PVN Magnocellular Neurosecretory CellsFrontiers in cellular neuroscience · 2019Article
- Inhibiting gustatory thalamus or medial amygdala has opposing effects on taste neophobia.Neurobiology of learning and memory · 2018Article
- The effects of amygdala and cortical inactivation on taste neophobia.Neurobiology of learning and memory · 2018Article
- Involvement of GABAergic and Adrenergic Neurotransmissions on Paraventricular Nucleus of Hypothalamus in the Control of Cardiac Function.Frontiers in physiology · 2018Article
- CBNaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- Descending Influences on Vestibulospinal and Vestibulosympathetic Reflexes.Frontiers in neurology · 2017Review
- Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-d-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure.Circulation. Heart failure · 2016Article
- Paraventricular Nucleus Modulates Excitatory Cardiovascular Reflexes during Electroacupuncture.Scientific reports · 2016Article
- Major Autonomic Neuroregulatory Pathways Underlying Short- and Long-Term Control of Cardiovascular Function.Current hypertension reports · 2016Review
- Attenuation of angiotensin type 2 receptor function in the rostral ventrolateral medullary pressor area of the spontaneously hypertensive rat.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Experiments were done in urethane-anesthetized, barodenervated, male Wistar rats. Chemical stimulation of the hypothalamic paraventricular nucleus (PVN) by unilateral microinjections of N-methyl-D-aspartic acid (NMDA) elicited increases in mean arterial pressure (MAP) and greater splanchnic nerve activity (GSNA). The increases in the MAP and GSNA induced by chemical stimulation of the PVN were significantly exaggerated by bilateral microinjections of D(-)-2-amino-7-phosphono-heptanoic acid (D-AP7) and 2,3-dioxo-6-nitro-1,2,3,4-tetrahydro-benzo[f]quinoxaline-7-sulfonamide disodium (NBQX) (ionotropic glutamate receptor antagonists) into the medial subnucleus of the nucleus tractus solitarius (mNTS). These results were confirmed by single unit recordings; i.e. excitation of mNTS barosensitive neurons caused by chemical stimulation of the ipsilateral PVN was blocked by application of D-AP7 and NBQX to these neurons. Bilateral microinjections of D-AP7 and NBQX into the mNTS elicited pressor responses which were significantly attenuated by inhibition of PVN neurons by bilateral microinjections of muscimol. Unilateral microinjections of fluorogold into the mNTS resulted in bilateral retrograde labeling of the PVN neurons. Unilateral microinjections of biotinylated dextran amine into the PVN resulted in anterograde labeling of axons and terminals in the mNTS bilaterally and the labeled terminals exhibited vesicular glutamate transporter-2 immunoreactivity. These results indicated that 1) a tonically active glutamatergic bilateral projection from the PVN to the mNTS exists; 2) bilateral blockade of ionotropic glutamate receptors in the mNTS exaggerates the increases in MAP and GSNA, but not heart rate, to the chemical stimulation of the PVN; and 3) this projection may serve as a restraint mechanism for excitatory cardiovascular effects of PVN stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.