ArticleBiophysical chemistry2008
Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.
Article in Biophysical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- The Structure, Functions and Potential Medicinal Effects of Chlorophylls Derived from Microalgae.Marine drugs · 2024Review
- ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.PLoS pathogens · 2021Article
- Diet and Dermatology: The Role of a Whole-food, Plant-based Diet in Preventing and Reversing Skin Aging-A Review.The Journal of clinical and aesthetic dermatology · 2020Review
- On the reliability of quantitation of biological effect in drug-interceptor-DNA systems.European biophysics journal : EBJ · 2013Article
- General analysis of competitive binding in drug-interceptor-DNA systems.European biophysics journal : EBJ · 2012Article
- Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan.European biophysics journal : EBJ · 2011Article
- Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.Methods in cell biology · 2011Review
- Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.European journal of pharmacology · 2009Review
- Induction of DNA damage response by the supravital probes of nucleic acids.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2009Article
- DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.Critical reviews in clinical laboratory sciencesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease binding of ICR-191 to DNA in a simple three-component competition system: CHL-ICR-DNA. Our data indicate a strong association of ICR-191 with CHL, stronger even than the association of ICR-191 with DNA. Calculations based on the measured affinity data show that a two- to three-fold excess of CHL reduces by about two-fold the concentration of the mutagen-DNA complex. We also exposed human leukemic HL-60 cells to ICR-191 in the absence and presence of CHL and measured the mutagen-induced DNA damage. The extent of DNA damage was assessed by analysis of histone H2AX phosphorylation. While ICR-191 induced significant increase in expression of phosphorylated H2AX (gammaH2AX), particularly in DNA replicating cells, this increase was totally abolished in the cells treated with ICR-191 in the presence of CHL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.